Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12056.143 | 0.8634 | 0.7287 | 1.0075 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 12056.143 | 0.8889 | 0.7794 | 1.0075 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 12056.143 | 0.7873 | 0.5774 | 1.0075 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12056.143 | 0.4430 | -0.1087 | 1.0075 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12056.143 | 0.0321 | -0.9342 | 1.0075 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12178.143 | 0.9355 | 0.8324 | 0.7617 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12178.143 | 0.9942 | 0.9847 | 0.7617 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12178.143 | 0.9312 | 0.8213 | 0.7617 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12178.143 | 0.9566 | 0.8868 | 0.7617 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12178.143 | 0.9247 | 0.8047 | 0.7617 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 12178.143 | 0.9504 | 0.8707 | 0.7617 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 12178.143 | 0.8466 | 0.6072 | 0.7617 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12178.143 | 0.5238 | -0.1444 | 0.7617 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12178.143 | 0.0394 | -0.9713 | 0.7617 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12291.143 | 1.0834 | 1.3064 | 0.5621 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12291.143 | 0.9893 | 0.9622 | 0.5621 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12291.143 | 1.0247 | 1.0888 | 0.5621 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12291.143 | 1.0262 | 1.0940 | 0.5621 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12291.143 | 1.0298 | 1.1074 | 0.5621 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 12291.143 | 1.0337 | 1.1214 | 0.5621 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 12291.143 | 0.9309 | 0.7609 | 0.5621 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12291.143 | 0.4394 | -0.5369 | 0.5621 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12291.143 | 0.0289 | -0.9964 | 0.5621 | |
| BT-483 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10696.143 | 1.0146 | 1.0566 | 0.5188 | |
| BT-483 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10696.143 | 1.0085 | 1.0328 | 0.5188 |