Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10880.143 | 0.8968 | 0.8690 | 1.6077 | |
| AU565 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10880.143 | 0.2715 | -0.1112 | 1.6077 | |
| AU565 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10880.143 | 0.0120 | -0.8723 | 1.6077 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10581.143 | 0.9296 | 0.8452 | 0.9062 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.192 | uM | 10581.143 | 0.8980 | 0.7761 | 0.9062 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.96 | uM | 10581.143 | 0.9454 | 0.8798 | 0.9062 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 4.8 | uM | 10581.143 | 0.8755 | 0.7270 | 0.9062 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 24 | uM | 10581.143 | 0.9459 | 0.8810 | 0.9062 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 120 | uM | 10581.143 | 0.9539 | 0.8984 | 0.9062 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 600 | uM | 10581.143 | 0.8026 | 0.5691 | 0.9062 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 3000 | uM | 10581.143 | 0.8092 | 0.5833 | 0.9062 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 15000 | uM | 10581.143 | 0.0450 | -0.9347 | 0.9062 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.0384 | uM | 11854.143 | 0.9899 | 0.9819 | 1.1185 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.192 | uM | 11854.143 | 1.0196 | 1.0351 | 1.1185 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.96 | uM | 11854.143 | 0.9913 | 0.9845 | 1.1185 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 4.8 | uM | 11854.143 | 1.0534 | 1.0952 | 1.1185 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 24 | uM | 11854.143 | 0.9607 | 0.9296 | 1.1185 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 120 | uM | 11854.143 | 0.9895 | 0.9812 | 1.1185 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 600 | uM | 11854.143 | 1.0445 | 1.0794 | 1.1185 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 3000 | uM | 11854.143 | 0.9236 | 0.8629 | 1.1185 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 15000 | uM | 11854.143 | 0.4983 | 0.0729 | 1.1185 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12056.143 | 0.9097 | 0.8206 | 1.0075 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12056.143 | 1.0023 | 1.0045 | 1.0075 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12056.143 | 0.9618 | 0.9241 | 1.0075 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12056.143 | 1.0084 | 1.0166 | 1.0075 |