Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7547.065 | 0.8076 | 0.6085 | 0.9808 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7547.065 | 0.5867 | 0.1612 | 0.9808 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7547.065 | 0.2392 | -0.5348 | 0.9808 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7547.065 | 0.1425 | -0.7257 | 0.9808 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7547.065 | 0.0600 | -0.8865 | 0.9808 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 10420.065 | 0.9568 | 0.8381 | 0.5232 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 10420.065 | 0.9711 | 0.8908 | 0.5232 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 10420.065 | 0.9791 | 0.9209 | 0.5232 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 10420.065 | 0.9321 | 0.7486 | 0.5232 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 10420.065 | 0.8870 | 0.5905 | 0.5232 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 10420.065 | 0.6829 | -0.0351 | 0.5232 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 10420.065 | 0.3690 | -0.7024 | 0.5232 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 10420.065 | 0.1760 | -0.9277 | 0.5232 | |
| UACC-812 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 10420.065 | 0.0945 | -0.9780 | 0.5232 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7552.065 | 0.9018 | 0.8255 | 1.1323 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7552.065 | 0.9690 | 0.9451 | 1.1323 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7552.065 | 0.9710 | 0.9486 | 1.1323 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7552.065 | 1.0185 | 1.0327 | 1.1323 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7552.065 | 0.9691 | 0.9454 | 1.1323 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7552.065 | 0.6917 | 0.4442 | 1.1323 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7552.065 | 0.4345 | -0.0421 | 1.1323 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7552.065 | 0.2620 | -0.3871 | 1.1323 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7552.065 | 0.2350 | -0.4434 | 1.1323 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7553.065 | 0.9353 | 0.8743 | 1.0305 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7553.065 | 0.9909 | 0.9824 | 1.0305 |