Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7553.065 | 0.9957 | 0.9917 | 1.0305 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7553.065 | 1.0414 | 1.0804 | 1.0305 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7553.065 | 1.0254 | 1.0492 | 1.0305 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7553.065 | 0.6982 | 0.4114 | 1.0305 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7553.065 | 0.4236 | -0.1311 | 1.0305 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7553.065 | 0.2321 | -0.5154 | 1.0305 | |
| ZR-75-1 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7553.065 | 0.2019 | -0.5766 | 1.0305 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7555.065 | 0.9389 | 0.9294 | 1.7561 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7555.065 | 0.9437 | 0.9351 | 1.7561 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7555.065 | 0.9695 | 0.9650 | 1.7561 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7555.065 | 0.9724 | 0.9684 | 1.7561 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7555.065 | 0.8916 | 0.8735 | 1.7561 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7555.065 | 0.4679 | 0.2978 | 1.7561 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7555.065 | 0.2133 | -0.1704 | 1.7561 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7555.065 | 0.0902 | -0.4916 | 1.7561 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7555.065 | 0.0784 | -0.5309 | 1.7561 | |
| 184A1 | NM | Basal | XRP44X | ELK3 | MAPK | 0.000341 | uM | 12509.157 | 1.0366 | 1.0569 | 1.2837 | |
| 184A1 | NM | Basal | XRP44X | ELK3 | MAPK | 0.00171 | uM | 12509.157 | 0.9641 | 0.9438 | 1.2837 | |
| 184A1 | NM | Basal | XRP44X | ELK3 | MAPK | 0.00853 | uM | 12509.157 | 1.0111 | 1.0173 | 1.2837 | |
| 184A1 | NM | Basal | XRP44X | ELK3 | MAPK | 0.0427 | uM | 12509.157 | 0.9234 | 0.8796 | 1.2837 | |
| 184A1 | NM | Basal | XRP44X | ELK3 | MAPK | 0.213 | uM | 12509.157 | 0.7560 | 0.6083 | 1.2837 | |
| 184A1 | NM | Basal | XRP44X | ELK3 | MAPK | 1.07 | uM | 12509.157 | 0.6377 | 0.4087 | 1.2837 | |
| 184A1 | NM | Basal | XRP44X | ELK3 | MAPK | 5.33 | uM | 12509.157 | 0.6308 | 0.3968 | 1.2837 | |
| 184A1 | NM | Basal | XRP44X | ELK3 | MAPK | 26.7 | uM | 12509.157 | 0.6016 | 0.3462 | 1.2837 | |
| 184A1 | NM | Basal | XRP44X | ELK3 | MAPK | 133 | uM | 12509.157 | 0.6456 | 0.4222 | 1.2837 |