Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | U-0126 | MEK | MAPK | 0.000853 | uM | 7812.029 | 0.4351 | -0.1562 | 0.9642 | |
| HCC1187 | TNBC | Basal A | U-0126 | MEK | MAPK | 0.00427 | uM | 7812.029 | 1.2580 | 1.5376 | 0.9642 | |
| HCC1187 | TNBC | Basal A | U-0126 | MEK | MAPK | 0.0213 | uM | 7812.029 | 1.2190 | 1.4561 | 0.9642 | |
| HCC1187 | TNBC | Basal A | U-0126 | MEK | MAPK | 0.107 | uM | 7812.029 | 0.7504 | 0.4849 | 0.9642 | |
| HCC1187 | TNBC | Basal A | U-0126 | MEK | MAPK | 0.533 | uM | 7812.029 | 1.2393 | 1.4984 | 0.9642 | |
| HCC1187 | TNBC | Basal A | U-0126 | MEK | MAPK | 2.67 | uM | 7812.029 | 1.4641 | 1.9699 | 0.9642 | |
| HCC1187 | TNBC | Basal A | U-0126 | MEK | MAPK | 13.3 | uM | 7812.029 | 1.2716 | 1.5660 | 0.9642 | |
| HCC1187 | TNBC | Basal A | U-0126 | MEK | MAPK | 66.7 | uM | 7812.029 | 0.5840 | 0.1448 | 0.9642 | |
| MDA-MB-436 | TNBC | Basal B | U-0126 | MEK | MAPK | 0.000171 | uM | 7898.029 | 1.5113 | 2.5692 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | U-0126 | MEK | MAPK | 0.000853 | uM | 7898.029 | 0.7119 | 0.2417 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | U-0126 | MEK | MAPK | 0.00427 | uM | 7898.029 | 1.4957 | 2.5177 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | U-0126 | MEK | MAPK | 0.0213 | uM | 7898.029 | 1.2886 | 1.8540 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | U-0126 | MEK | MAPK | 0.107 | uM | 7898.029 | 0.9342 | 0.8180 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | U-0126 | MEK | MAPK | 0.533 | uM | 7898.029 | 1.2508 | 1.7376 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | U-0126 | MEK | MAPK | 2.67 | uM | 7898.029 | 1.2465 | 1.7241 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | U-0126 | MEK | MAPK | 13.3 | uM | 7898.029 | 1.2965 | 1.8788 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | U-0126 | MEK | MAPK | 66.7 | uM | 7898.029 | 0.9303 | 0.8073 | 0.7130 | |
| 184A1 | NM | Basal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12509.143 | 1.0194 | 1.0289 | 1.3392 | |
| 184A1 | NM | Basal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12509.143 | 0.9572 | 0.9357 | 1.3392 | |
| 184A1 | NM | Basal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12509.143 | 1.0208 | 1.0310 | 1.3392 | |
| 184A1 | NM | Basal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12509.143 | 0.9418 | 0.9124 | 1.3392 | |
| 184A1 | NM | Basal | Valproic acid | HDAC | HDAC | 24 | uM | 12509.143 | 0.9927 | 0.9890 | 1.3392 | |
| 184A1 | NM | Basal | Valproic acid | HDAC | HDAC | 120 | uM | 12509.143 | 0.8877 | 0.8297 | 1.3392 | |
| 184A1 | NM | Basal | Valproic acid | HDAC | HDAC | 600 | uM | 12509.143 | 0.7624 | 0.6332 | 1.3392 | |
| 184A1 | NM | Basal | Valproic acid | HDAC | HDAC | 3000 | uM | 12509.143 | 0.5064 | 0.2033 | 1.3392 |