Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 0.0107 | uM | 7552.074 | 1.0209 | 1.0457 | 0.9174 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 0.0533 | uM | 7552.074 | 0.9680 | 0.9303 | 0.9174 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 0.267 | uM | 7552.074 | 0.9294 | 0.8466 | 0.9174 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 1.33 | uM | 7552.074 | 0.8670 | 0.7119 | 0.9174 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 6.67 | uM | 7552.074 | 0.8262 | 0.6241 | 0.9174 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 33.3 | uM | 7552.074 | 0.6554 | 0.2618 | 0.9174 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 0.0000853 | uM | 7553.074 | 0.9274 | 0.8477 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 0.000427 | uM | 7553.074 | 0.9157 | 0.8231 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 0.00213 | uM | 7553.074 | 0.9650 | 0.9266 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 0.0107 | uM | 7553.074 | 0.9750 | 0.9476 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 0.0533 | uM | 7553.074 | 0.9859 | 0.9703 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 0.267 | uM | 7553.074 | 0.9565 | 0.9088 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 1.33 | uM | 7553.074 | 0.9298 | 0.8527 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 6.67 | uM | 7553.074 | 0.7920 | 0.5653 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Triciribine | AKT | AKT | 33.3 | uM | 7553.074 | 0.6236 | 0.2175 | 0.9515 | |
| ZR75B | HR+ | Luminal | Triciribine | AKT | AKT | 0.0000853 | uM | 7555.074 | 0.9623 | 0.9544 | 1.6682 | |
| ZR75B | HR+ | Luminal | Triciribine | AKT | AKT | 0.000427 | uM | 7555.074 | 0.8884 | 0.8631 | 1.6682 | |
| ZR75B | HR+ | Luminal | Triciribine | AKT | AKT | 0.00213 | uM | 7555.074 | 0.8875 | 0.8619 | 1.6682 | |
| ZR75B | HR+ | Luminal | Triciribine | AKT | AKT | 0.0107 | uM | 7555.074 | 0.8718 | 0.8421 | 1.6682 | |
| ZR75B | HR+ | Luminal | Triciribine | AKT | AKT | 0.0533 | uM | 7555.074 | 0.9358 | 0.9220 | 1.6682 | |
| ZR75B | HR+ | Luminal | Triciribine | AKT | AKT | 0.267 | uM | 7555.074 | 0.8143 | 0.7683 | 1.6682 | |
| ZR75B | HR+ | Luminal | Triciribine | AKT | AKT | 1.33 | uM | 7555.074 | 0.7052 | 0.6221 | 1.6682 | |
| ZR75B | HR+ | Luminal | Triciribine | AKT | AKT | 6.67 | uM | 7555.074 | 0.3962 | 0.1482 | 1.6682 | |
| ZR75B | HR+ | Luminal | Triciribine | AKT | AKT | 33.3 | uM | 7555.074 | 0.2816 | -0.0643 | 1.6682 | |
| HCC1187 | TNBC | Basal A | U-0126 | MEK | MAPK | 0.000171 | uM | 7812.029 | 1.2379 | 1.4954 | 0.9642 |