Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7903.036 | 0.9958 | 0.9915 | 1.0022 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7903.036 | 0.9998 | 0.9996 | 1.0022 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7903.036 | 0.9877 | 0.9754 | 1.0022 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7903.036 | 1.0015 | 1.0031 | 1.0022 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7903.036 | 0.9712 | 0.9425 | 1.0022 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7903.036 | 0.8245 | 0.6497 | 1.0022 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7903.036 | 0.7409 | 0.4827 | 1.0022 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7903.036 | 0.7608 | 0.5226 | 1.0022 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7903.036 | 0.7379 | 0.4768 | 1.0022 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9708.012 | 1.0564 | 1.1152 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9708.012 | 1.1126 | 1.2301 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9708.012 | 0.9623 | 0.9231 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9708.012 | 1.0533 | 1.1088 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9708.012 | 1.0284 | 1.0579 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9708.012 | 0.7693 | 0.5302 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9708.012 | 0.7892 | 0.5707 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9708.012 | 0.7364 | 0.4637 | 0.9799 | |
| MDA-MB-453 | TNBC | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9708.012 | 0.7299 | 0.4504 | 0.9799 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 7905.012 | 1.0647 | 1.1868 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 7905.012 | 0.7872 | 0.4229 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 7905.012 | 1.0868 | 1.2514 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 7905.012 | 0.8887 | 0.6910 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 7905.012 | 1.1546 | 1.4540 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 7905.012 | 1.1171 | 1.3415 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 7905.012 | 1.0659 | 1.1903 | 0.7027 |