Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7900.036 | 0.6391 | 0.1426 | 0.7997 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7900.036 | 0.8067 | 0.5290 | 0.7997 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7900.036 | 1.0325 | 1.0815 | 0.7997 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7900.036 | 0.8934 | 0.7371 | 0.7997 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7900.036 | 0.9591 | 0.8981 | 0.7997 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7900.036 | 1.0999 | 1.2529 | 0.7997 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7900.036 | 0.6571 | 0.1830 | 0.7997 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 7902.05 | 1.0971 | 1.1048 | 1.8149 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 7902.05 | 0.7786 | 0.7424 | 1.8149 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7902.05 | 1.0894 | 1.0966 | 1.8149 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7902.05 | 0.7662 | 0.7270 | 1.8149 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7902.05 | 1.0182 | 1.0200 | 1.8149 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7902.05 | 0.7968 | 0.7648 | 1.8149 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7902.05 | 1.0730 | 1.0792 | 1.8149 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7902.05 | 0.9802 | 0.9781 | 1.8149 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7902.05 | 0.7047 | 0.6492 | 1.8149 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 10266.024 | 1.1342 | 1.4252 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 10266.024 | 0.8268 | 0.4947 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 10266.024 | 1.1133 | 1.3571 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 10266.024 | 0.8837 | 0.6552 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 10266.024 | 1.0340 | 1.1052 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 10266.024 | 0.9066 | 0.7213 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 10266.024 | 1.0322 | 1.0995 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 10266.024 | 0.9940 | 0.9816 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 10266.024 | 0.6795 | 0.1069 | 0.6533 |