Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Triciribine | AKT | AKT | 6.67 | uM | 7535.074 | 0.5630 | 0.1576 | 1.0507 | |
| SUM229PE | TNBC | - | Triciribine | AKT | AKT | 33.3 | uM | 7535.074 | 0.5141 | 0.0617 | 1.0507 | |
| SUM229PE | TNBC | - | Triciribine | AKT | AKT | 0.0000853 | uM | 7537.074 | 0.9406 | 0.9400 | 2.0080 | |
| SUM229PE | TNBC | - | Triciribine | AKT | AKT | 0.000427 | uM | 7537.074 | 0.9592 | 0.9590 | 2.0080 | |
| SUM229PE | TNBC | - | Triciribine | AKT | AKT | 0.00213 | uM | 7537.074 | 0.9302 | 0.9293 | 2.0080 | |
| SUM229PE | TNBC | - | Triciribine | AKT | AKT | 0.0107 | uM | 7537.074 | 0.8793 | 0.8759 | 2.0080 | |
| SUM229PE | TNBC | - | Triciribine | AKT | AKT | 0.0533 | uM | 7537.074 | 0.7931 | 0.7820 | 2.0080 | |
| SUM229PE | TNBC | - | Triciribine | AKT | AKT | 0.267 | uM | 7537.074 | 0.7186 | 0.6965 | 2.0080 | |
| SUM229PE | TNBC | - | Triciribine | AKT | AKT | 1.33 | uM | 7537.074 | 0.6726 | 0.6415 | 2.0080 | |
| SUM229PE | TNBC | - | Triciribine | AKT | AKT | 6.67 | uM | 7537.074 | 0.5926 | 0.5412 | 2.0080 | |
| SUM229PE | TNBC | - | Triciribine | AKT | AKT | 33.3 | uM | 7537.074 | 0.4924 | 0.4054 | 2.0080 | |
| SUM52PE | HR+ | Luminal | Triciribine | AKT | AKT | 0.0000853 | uM | 7541.074 | 0.9981 | 0.9971 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Triciribine | AKT | AKT | 0.000427 | uM | 7541.074 | 0.9992 | 0.9988 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Triciribine | AKT | AKT | 0.00213 | uM | 7541.074 | 1.0098 | 1.0149 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Triciribine | AKT | AKT | 0.0107 | uM | 7541.074 | 0.9070 | 0.8577 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Triciribine | AKT | AKT | 0.0533 | uM | 7541.074 | 0.8342 | 0.7437 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Triciribine | AKT | AKT | 0.267 | uM | 7541.074 | 0.7993 | 0.6884 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Triciribine | AKT | AKT | 1.33 | uM | 7541.074 | 0.7363 | 0.5867 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Triciribine | AKT | AKT | 6.67 | uM | 7541.074 | 0.6474 | 0.4395 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Triciribine | AKT | AKT | 33.3 | uM | 7541.074 | 0.4666 | 0.1238 | 1.3223 | |
| T47D | HR+ | Luminal | Triciribine | AKT | AKT | 0.0000853 | uM | 7542.074 | 0.9417 | 0.9198 | 1.4673 | |
| T47D | HR+ | Luminal | Triciribine | AKT | AKT | 0.000427 | uM | 7542.074 | 0.9598 | 0.9448 | 1.4673 | |
| T47D | HR+ | Luminal | Triciribine | AKT | AKT | 0.00213 | uM | 7542.074 | 0.9758 | 0.9669 | 1.4673 | |
| T47D | HR+ | Luminal | Triciribine | AKT | AKT | 0.0107 | uM | 7542.074 | 0.9531 | 0.9356 | 1.4673 | |
| T47D | HR+ | Luminal | Triciribine | AKT | AKT | 0.0533 | uM | 7542.074 | 0.8054 | 0.7257 | 1.4673 |