Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 12001.169 | 0.9517 | 0.8671 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 12001.169 | 0.9618 | 0.8945 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 12001.169 | 0.9087 | 0.7508 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 12001.169 | 0.7689 | 0.3879 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 12001.169 | 0.3845 | -0.4704 | 0.7194 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10693.15 | 1.0288 | 1.0746 | 0.7763 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10693.15 | 1.0000 | 1.0001 | 0.7763 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10693.15 | 0.9937 | 0.9837 | 0.7763 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10693.15 | 1.0146 | 1.0376 | 0.7763 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10693.15 | 1.0226 | 1.0585 | 0.7763 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10693.15 | 0.9421 | 0.8520 | 0.7763 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10693.15 | 0.9434 | 0.8555 | 0.7763 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10693.15 | 0.7884 | 0.4723 | 0.7763 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10693.15 | 0.4951 | -0.1914 | 0.7763 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11936.16 | 0.9460 | 0.8799 | 0.8962 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11936.16 | 0.8688 | 0.7096 | 0.8962 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 11936.16 | 0.9604 | 0.9117 | 0.8962 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 11936.16 | 0.9321 | 0.8492 | 0.8962 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 11936.16 | 0.9543 | 0.8982 | 0.8962 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 11936.16 | 0.8985 | 0.7748 | 0.8962 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 11936.16 | 0.8261 | 0.6161 | 0.8962 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 11936.16 | 0.8408 | 0.6482 | 0.8962 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 11936.16 | 0.6279 | 0.1900 | 0.8962 | |
| HCC1569 | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10872.15 | 0.9630 | 0.9541 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10872.15 | 0.8847 | 0.8548 | 1.6255 |