Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10753.15 | 0.3540 | -0.0411 | 1.4129 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10753.15 | 0.2385 | -0.2749 | 1.4129 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10753.15 | 0.1265 | -0.5371 | 1.4129 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 12000.169 | 0.9379 | 0.8558 | 0.8565 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 12000.169 | 0.9581 | 0.9024 | 0.8565 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 12000.169 | 0.9836 | 0.9617 | 0.8565 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 12000.169 | 0.9408 | 0.8624 | 0.8565 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 12000.169 | 0.7913 | 0.5218 | 0.8565 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 12000.169 | 0.8845 | 0.7329 | 0.8565 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 12000.169 | 0.7697 | 0.4732 | 0.8565 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 12000.169 | 0.3858 | -0.3422 | 0.8565 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 12000.169 | 0.0138 | -0.9866 | 0.8565 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 12084.16 | 1.0333 | 1.0595 | 1.1178 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 12084.16 | 1.0046 | 1.0082 | 1.1178 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 12084.16 | 1.0275 | 1.0490 | 1.1178 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 12084.16 | 1.0137 | 1.0245 | 1.1178 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 12084.16 | 0.9118 | 0.8414 | 1.1178 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 12084.16 | 0.9098 | 0.8378 | 1.1178 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 12084.16 | 0.8654 | 0.7573 | 1.1178 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 12084.16 | 0.8961 | 0.8130 | 1.1178 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 12084.16 | 0.1190 | -0.7022 | 1.1178 | |
| HCC1419 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 12001.169 | 0.9310 | 0.8106 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 12001.169 | 0.9543 | 0.8741 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 12001.169 | 0.9277 | 0.8018 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 12001.169 | 0.9958 | 0.9884 | 0.7194 |