Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 12070.16 | 0.4018 | -0.3200 | 0.8453 | |
| HCC1143 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 12112.16 | 0.9591 | 0.9517 | 1.7073 | |
| HCC1143 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 12112.16 | 0.9640 | 0.9575 | 1.7073 | |
| HCC1143 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 12112.16 | 0.9545 | 0.9462 | 1.7073 | |
| HCC1143 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 12112.16 | 0.9623 | 0.9555 | 1.7073 | |
| HCC1143 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 12112.16 | 0.8922 | 0.8707 | 1.7073 | |
| HCC1143 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 12112.16 | 0.6640 | 0.5736 | 1.7073 | |
| HCC1143 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 12112.16 | 0.6126 | 0.5010 | 1.7073 | |
| HCC1143 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 12112.16 | 0.5251 | 0.3715 | 1.7073 | |
| HCC1143 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 12112.16 | 0.2924 | -0.0267 | 1.7073 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 10518.138 | 1.0632 | 1.0935 | 1.3413 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 10518.138 | 0.9274 | 0.8907 | 1.3413 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 10518.138 | 0.9890 | 0.9836 | 1.3413 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 10518.138 | 0.9977 | 0.9965 | 1.3413 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 10518.138 | 0.4676 | 0.1347 | 1.3413 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 10518.138 | 0.4056 | 0.0205 | 1.3413 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 10518.138 | 0.3770 | -0.0336 | 1.3413 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 10518.138 | 0.2290 | -0.3335 | 1.3413 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 10518.138 | 0.1401 | -0.5380 | 1.3413 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10753.15 | 0.9954 | 0.9935 | 1.4129 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10753.15 | 0.8983 | 0.8538 | 1.4129 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10753.15 | 0.9532 | 0.9332 | 1.4129 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10753.15 | 0.9174 | 0.8816 | 1.4129 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10753.15 | 0.8706 | 0.8131 | 1.4129 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10753.15 | 0.3768 | 0.0023 | 1.4129 |