Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM190PT | HER2amp | Luminal | Torkinib | 2 | uM | 15358.211 | 0.2895 | -0.2013 | 1.3504 | |||
| SUM190PT | HER2amp | Luminal | Torkinib | 10 | uM | 15358.211 | 0.1805 | -0.4372 | 1.3504 | |||
| SUM190PT | HER2amp | Luminal | Torkinib | 50 | uM | 15358.211 | 0.0982 | -0.6414 | 1.3504 | |||
| SUM225CWN | HER2amp | Basal A | Torkinib | 0.000128 | uM | 15403.211 | 1.0396 | 1.1054 | 0.7553 | |||
| SUM225CWN | HER2amp | Basal A | Torkinib | 0.00064 | uM | 15403.211 | 0.9026 | 0.7462 | 0.7553 | |||
| SUM225CWN | HER2amp | Basal A | Torkinib | 0.0032 | uM | 15403.211 | 0.9005 | 0.7409 | 0.7553 | |||
| SUM225CWN | HER2amp | Basal A | Torkinib | 0.016 | uM | 15403.211 | 0.8359 | 0.5776 | 0.7553 | |||
| SUM225CWN | HER2amp | Basal A | Torkinib | 0.08 | uM | 15403.211 | 0.7340 | 0.3280 | 0.7553 | |||
| SUM225CWN | HER2amp | Basal A | Torkinib | 0.4 | uM | 15403.211 | 0.5482 | -0.0976 | 0.7553 | |||
| SUM225CWN | HER2amp | Basal A | Torkinib | 2 | uM | 15403.211 | 0.4587 | -0.2874 | 0.7553 | |||
| SUM225CWN | HER2amp | Basal A | Torkinib | 10 | uM | 15403.211 | 0.3320 | -0.5355 | 0.7553 | |||
| SUM225CWN | HER2amp | Basal A | Torkinib | 50 | uM | 15403.211 | 0.2673 | -0.6514 | 0.7553 | |||
| SUM229PE | TNBC | - | Torkinib | 0.000128 | uM | 15359.211 | 1.0648 | 1.0894 | 1.4356 | |||
| SUM229PE | TNBC | - | Torkinib | 0.00064 | uM | 15359.211 | 0.9445 | 0.9221 | 1.4356 | |||
| SUM229PE | TNBC | - | Torkinib | 0.0032 | uM | 15359.211 | 0.9454 | 0.9232 | 1.4356 | |||
| SUM229PE | TNBC | - | Torkinib | 0.016 | uM | 15359.211 | 0.8418 | 0.7739 | 1.4356 | |||
| SUM229PE | TNBC | - | Torkinib | 0.08 | uM | 15359.211 | 0.7266 | 0.6011 | 1.4356 | |||
| SUM229PE | TNBC | - | Torkinib | 0.4 | uM | 15359.211 | 0.5623 | 0.3393 | 1.4356 | |||
| SUM229PE | TNBC | - | Torkinib | 2 | uM | 15359.211 | 0.7161 | 0.5850 | 1.4356 | |||
| SUM229PE | TNBC | - | Torkinib | 10 | uM | 15359.211 | 0.4033 | 0.0625 | 1.4356 | |||
| SUM229PE | TNBC | - | Torkinib | 50 | uM | 15359.211 | 0.4436 | 0.1354 | 1.4356 | |||
| T47D | HR+ | Luminal | Torkinib | 0.000128 | uM | 15340.211 | 0.7519 | 0.6675 | 1.5685 | |||
| T47D | HR+ | Luminal | Torkinib | 0.00064 | uM | 15340.211 | 0.5691 | 0.3963 | 1.5685 | |||
| T47D | HR+ | Luminal | Torkinib | 0.0032 | uM | 15340.211 | 0.4893 | 0.2680 | 1.5685 | |||
| T47D | HR+ | Luminal | Torkinib | 0.016 | uM | 15340.211 | 0.3791 | 0.0776 | 1.5685 |