Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Torkinib | 0.00064 | uM | 15356.211 | 0.7200 | 0.5567 | 1.3112 | |||
| SK-BR-3 | HER2amp | Luminal | Torkinib | 0.0032 | uM | 15356.211 | 0.6084 | 0.3691 | 1.3112 | |||
| SK-BR-3 | HER2amp | Luminal | Torkinib | 0.016 | uM | 15356.211 | 0.4627 | 0.1111 | 1.3112 | |||
| SK-BR-3 | HER2amp | Luminal | Torkinib | 0.08 | uM | 15356.211 | 0.4070 | 0.0075 | 1.3112 | |||
| SK-BR-3 | HER2amp | Luminal | Torkinib | 0.4 | uM | 15356.211 | 0.3853 | -0.0336 | 1.3112 | |||
| SK-BR-3 | HER2amp | Luminal | Torkinib | 2 | uM | 15356.211 | 0.3377 | -0.1261 | 1.3112 | |||
| SK-BR-3 | HER2amp | Luminal | Torkinib | 10 | uM | 15356.211 | 0.2716 | -0.2599 | 1.3112 | |||
| SK-BR-3 | HER2amp | Luminal | Torkinib | 50 | uM | 15356.211 | 0.2141 | -0.3826 | 1.3112 | |||
| SUM1315MO2 | TNBC | Basal B | Torkinib | 0.000128 | uM | 15401.211 | 0.7874 | 0.1130 | 0.4079 | |||
| SUM1315MO2 | TNBC | Basal B | Torkinib | 0.00064 | uM | 15401.211 | 0.6179 | -0.3855 | 0.4079 | |||
| SUM1315MO2 | TNBC | Basal B | Torkinib | 0.0032 | uM | 15401.211 | 0.5350 | -0.5683 | 0.4079 | |||
| SUM1315MO2 | TNBC | Basal B | Torkinib | 0.016 | uM | 15401.211 | 0.5118 | -0.6129 | 0.4079 | |||
| SUM1315MO2 | TNBC | Basal B | Torkinib | 0.08 | uM | 15401.211 | 0.4242 | -0.7557 | 0.4079 | |||
| SUM1315MO2 | TNBC | Basal B | Torkinib | 0.4 | uM | 15401.211 | 0.4089 | -0.7767 | 0.4079 | |||
| SUM1315MO2 | TNBC | Basal B | Torkinib | 2 | uM | 15401.211 | 0.3372 | -0.8608 | 0.4079 | |||
| SUM1315MO2 | TNBC | Basal B | Torkinib | 10 | uM | 15401.211 | 0.2679 | -0.9208 | 0.4079 | |||
| SUM1315MO2 | TNBC | Basal B | Torkinib | 50 | uM | 15401.211 | 0.2021 | -0.9603 | 0.4079 | |||
| SUM149PT | TNBC | Basal B | Torkinib | 0.000128 | uM | 15357.211 | 0.8176 | 0.8046 | 1.9588 | |||
| SUM149PT | TNBC | Basal B | Torkinib | 0.00064 | uM | 15357.211 | 0.6932 | 0.6588 | 1.9588 | |||
| SUM149PT | TNBC | Basal B | Torkinib | 0.0032 | uM | 15357.211 | 0.6784 | 0.6406 | 1.9588 | |||
| SUM149PT | TNBC | Basal B | Torkinib | 0.016 | uM | 15357.211 | 0.5681 | 0.4985 | 1.9588 | |||
| SUM149PT | TNBC | Basal B | Torkinib | 0.08 | uM | 15357.211 | 0.4959 | 0.3980 | 1.9588 | |||
| SUM149PT | TNBC | Basal B | Torkinib | 0.4 | uM | 15357.211 | 0.3785 | 0.2179 | 1.9588 | |||
| SUM149PT | TNBC | Basal B | Torkinib | 2 | uM | 15357.211 | 0.2618 | 0.0090 | 1.9588 | |||
| SUM149PT | TNBC | Basal B | Torkinib | 10 | uM | 15357.211 | 0.1674 | -0.1970 | 1.9588 |