Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Torkinib | 0.016 | uM | 15396.211 | 0.5971 | 0.1374 | 0.9137 | |||
| MDA-MB-361 | HER2amp | Luminal | Torkinib | 0.08 | uM | 15396.211 | 0.4368 | -0.1922 | 0.9137 | |||
| MDA-MB-361 | HER2amp | Luminal | Torkinib | 0.4 | uM | 15396.211 | 0.3472 | -0.3717 | 0.9137 | |||
| MDA-MB-361 | HER2amp | Luminal | Torkinib | 2 | uM | 15396.211 | 0.2796 | -0.5043 | 0.9137 | |||
| MDA-MB-361 | HER2amp | Luminal | Torkinib | 10 | uM | 15396.211 | 0.2469 | -0.5673 | 0.9137 | |||
| MDA-MB-361 | HER2amp | Luminal | Torkinib | 50 | uM | 15396.211 | 0.2261 | -0.6071 | 0.9137 | |||
| MDA-MB-415 | HR+ | Luminal | Torkinib | 0.000128 | uM | 15325.211 | 0.8859 | 0.7964 | 1.1289 | |||
| MDA-MB-415 | HR+ | Luminal | Torkinib | 0.00064 | uM | 15325.211 | 0.7483 | 0.5469 | 1.1289 | |||
| MDA-MB-415 | HR+ | Luminal | Torkinib | 0.0032 | uM | 15325.211 | 0.6915 | 0.4425 | 1.1289 | |||
| MDA-MB-415 | HR+ | Luminal | Torkinib | 0.016 | uM | 15325.211 | 0.5120 | 0.1053 | 1.1289 | |||
| MDA-MB-415 | HR+ | Luminal | Torkinib | 0.08 | uM | 15325.211 | 0.3975 | -0.1167 | 1.1289 | |||
| MDA-MB-415 | HR+ | Luminal | Torkinib | 0.4 | uM | 15325.211 | 0.2896 | -0.3328 | 1.1289 | |||
| MDA-MB-415 | HR+ | Luminal | Torkinib | 2 | uM | 15325.211 | 0.1837 | -0.5542 | 1.1289 | |||
| MDA-MB-415 | HR+ | Luminal | Torkinib | 10 | uM | 15325.211 | 0.0979 | -0.7447 | 1.1289 | |||
| MDA-MB-415 | HR+ | Luminal | Torkinib | 50 | uM | 15325.211 | 0.0395 | -0.8858 | 1.1289 | |||
| MDA-MB-453 | TNBC | Luminal | Torkinib | 0.000128 | uM | 15398.211 | 0.8715 | 0.7572 | 1.0628 | |||
| MDA-MB-453 | TNBC | Luminal | Torkinib | 0.00064 | uM | 15398.211 | 0.7355 | 0.4980 | 1.0628 | |||
| MDA-MB-453 | TNBC | Luminal | Torkinib | 0.0032 | uM | 15398.211 | 0.6083 | 0.2529 | 1.0628 | |||
| MDA-MB-453 | TNBC | Luminal | Torkinib | 0.016 | uM | 15398.211 | 0.5267 | 0.0941 | 1.0628 | |||
| MDA-MB-453 | TNBC | Luminal | Torkinib | 0.08 | uM | 15398.211 | 0.3898 | -0.1759 | 1.0628 | |||
| MDA-MB-453 | TNBC | Luminal | Torkinib | 0.4 | uM | 15398.211 | 0.3411 | -0.2730 | 1.0628 | |||
| MDA-MB-453 | TNBC | Luminal | Torkinib | 2 | uM | 15398.211 | 0.3099 | -0.3357 | 1.0628 | |||
| MDA-MB-453 | TNBC | Luminal | Torkinib | 10 | uM | 15398.211 | 0.2617 | -0.4334 | 1.0628 | |||
| MDA-MB-453 | TNBC | Luminal | Torkinib | 50 | uM | 15398.211 | 0.1812 | -0.5991 | 1.0628 | |||
| SK-BR-3 | HER2amp | Luminal | Torkinib | 0.000128 | uM | 15356.211 | 0.8761 | 0.8080 | 1.3112 |