Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | TCS PIM-1 1 | Pim kinase | PIM | 26.7 | uM | 12566.135 | 0.2981 | -0.0446 | 1.6384 | |
| 184B5 | NM | Basal | TCS PIM-1 1 | Pim kinase | PIM | 133 | uM | 12566.135 | 0.2760 | -0.0883 | 1.6384 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.000341 | uM | 12224.135 | 0.9479 | 0.8989 | 1.0314 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.00171 | uM | 12224.135 | 0.9569 | 0.9164 | 1.0314 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.00853 | uM | 12224.135 | 0.9509 | 0.9048 | 1.0314 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.0427 | uM | 12224.135 | 0.9521 | 0.9071 | 1.0314 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.213 | uM | 12224.135 | 0.9243 | 0.8530 | 1.0314 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 1.07 | uM | 12224.135 | 0.9749 | 0.9513 | 1.0314 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 5.33 | uM | 12224.135 | 0.9586 | 0.9197 | 1.0314 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 26.7 | uM | 12224.135 | 0.9538 | 0.9103 | 1.0314 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 133 | uM | 12224.135 | 0.8903 | 0.7869 | 1.0314 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.000171 | uM | 10880.148 | 0.9363 | 0.9253 | 1.7293 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.000853 | uM | 10880.148 | 0.9821 | 0.9792 | 1.7293 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.00427 | uM | 10880.148 | 0.9405 | 0.9303 | 1.7293 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.0213 | uM | 10880.148 | 0.9470 | 0.9380 | 1.7293 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.107 | uM | 10880.148 | 0.9617 | 0.9553 | 1.7293 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.533 | uM | 10880.148 | 1.0001 | 1.0001 | 1.7293 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 2.67 | uM | 10880.148 | 0.9929 | 0.9918 | 1.7293 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 13.3 | uM | 10880.148 | 0.9349 | 0.9237 | 1.7293 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 66.7 | uM | 10880.148 | 0.6722 | 0.5895 | 1.7293 | |
| BT-20 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.000341 | uM | 10581.135 | 1.0510 | 1.2381 | 0.4426 | |
| BT-20 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.00171 | uM | 10581.135 | 0.9620 | 0.8323 | 0.4426 | |
| BT-20 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.00853 | uM | 10581.135 | 1.0111 | 1.0507 | 0.4426 | |
| BT-20 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.0427 | uM | 10581.135 | 0.9589 | 0.8192 | 0.4426 | |
| BT-20 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.213 | uM | 10581.135 | 1.0223 | 1.1021 | 0.4426 |