Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12333.152 | 1.0091 | 1.0247 | 0.7371 | |
| MDA-MB-415 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12333.152 | 0.9812 | 0.9492 | 0.7371 | |
| MDA-MB-415 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12333.152 | 1.0444 | 1.1215 | 0.7371 | |
| MDA-MB-415 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12333.152 | 0.9701 | 0.9193 | 0.7371 | |
| MDA-MB-415 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12333.152 | 0.9485 | 0.8616 | 0.7371 | |
| MDA-MB-415 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12333.152 | 1.0141 | 1.0385 | 0.7371 | |
| MDA-MB-415 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12333.152 | 0.5190 | -0.1784 | 0.7371 | |
| MDA-MB-415 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12333.152 | 0.3439 | -0.5300 | 0.7371 | |
| MDA-MB-415 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12333.152 | 0.2983 | -0.6124 | 0.7371 | |
| MDA-MB-453 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12414.152 | 0.9842 | 0.9721 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12414.152 | 0.9243 | 0.8657 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12414.152 | 0.9829 | 0.9697 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12414.152 | 0.9516 | 0.9143 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12414.152 | 0.9766 | 0.9586 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12414.152 | 0.8478 | 0.7287 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12414.152 | 0.4091 | -0.0917 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12414.152 | 0.0312 | -0.9065 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12414.152 | 0.0341 | -0.8986 | 1.1325 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10644.14 | 1.0440 | 1.2107 | 0.4302 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 10644.14 | 0.9508 | 0.7786 | 0.4302 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 10644.14 | 1.0434 | 1.2079 | 0.4302 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10644.14 | 1.0256 | 1.1211 | 0.4302 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 10644.14 | 1.0774 | 1.3784 | 0.4302 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10644.14 | 0.3409 | -0.8361 | 0.4302 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 1.33 | uM | 10644.14 | 0.0510 | -0.9980 | 0.4302 |