Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 6.67 | uM | 7500.067 | 0.9148 | 0.7657 | 0.7143 | |
| MDA-MB-175-VII | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 7500.067 | 0.0082 | -0.9976 | 0.7143 | |
| MDA-MB-175-VII | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 7500.067 | 0.0025 | -0.9996 | 0.7143 | |
| MDA-MB-231 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 7504.067 | 1.0270 | 1.0275 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 7504.067 | 1.0580 | 1.0586 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 7504.067 | 1.0495 | 1.0500 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0533 | uM | 7504.067 | 1.2359 | 1.2290 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.267 | uM | 7504.067 | 1.2003 | 1.1959 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 1.33 | uM | 7504.067 | 1.0757 | 1.0761 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 6.67 | uM | 7504.067 | 0.7081 | 0.6762 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 7504.067 | 0.0075 | -0.8366 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 7504.067 | 0.0003 | -0.9685 | 1.9544 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 7506.067 | 0.9678 | 0.9379 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 7506.067 | 1.0200 | 1.0385 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 7506.067 | 1.0277 | 1.0534 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0533 | uM | 7506.067 | 1.0491 | 1.0946 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.267 | uM | 7506.067 | 1.0536 | 1.1032 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 1.33 | uM | 7506.067 | 1.0556 | 1.1070 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 6.67 | uM | 7506.067 | 0.9525 | 0.9084 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 7506.067 | 0.0128 | -0.9699 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 7506.067 | 0.0044 | -0.9893 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 7507.067 | 0.9962 | 0.9923 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 7507.067 | 0.9829 | 0.9653 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 7507.067 | 1.0485 | 1.0983 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0533 | uM | 7507.067 | 0.9990 | 0.9980 | 0.9880 |