Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 0.00427 | uM | 10874.153 | 0.9070 | 0.7821 | 0.8467 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 0.0213 | uM | 10874.153 | 0.9003 | 0.7666 | 0.8467 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 0.107 | uM | 10874.153 | 0.9453 | 0.8714 | 0.8467 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 0.533 | uM | 10874.153 | 0.9530 | 0.8895 | 0.8467 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 2.67 | uM | 10874.153 | 0.8910 | 0.7452 | 0.8467 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 13.3 | uM | 10874.153 | 0.3535 | -0.4144 | 0.8467 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 66.7 | uM | 10874.153 | 0.0274 | -0.9715 | 0.8467 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 0.000171 | uM | 12220.158 | 1.0079 | 1.0369 | 0.4308 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 0.000853 | uM | 12220.158 | 1.0083 | 1.0388 | 0.4308 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 0.00427 | uM | 12220.158 | 1.0238 | 1.1123 | 0.4308 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 0.0213 | uM | 12220.158 | 1.0208 | 1.0978 | 0.4308 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 0.107 | uM | 12220.158 | 1.0108 | 1.0507 | 0.4308 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 0.533 | uM | 12220.158 | 0.8928 | 0.5371 | 0.4308 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 2.67 | uM | 12220.158 | 0.8475 | 0.3621 | 0.4308 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 13.3 | uM | 12220.158 | 0.2699 | -0.9043 | 0.4308 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 66.7 | uM | 12220.158 | 0.0207 | -0.9998 | 0.4308 | |
| SK-BR-3 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.000171 | uM | 11851.158 | 0.9895 | 0.9852 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.000853 | uM | 11851.158 | 1.0050 | 1.0070 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.00427 | uM | 11851.158 | 0.9594 | 0.9426 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.0213 | uM | 11851.158 | 0.9548 | 0.9360 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.107 | uM | 11851.158 | 0.9514 | 0.9311 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 0.533 | uM | 11851.158 | 0.8447 | 0.7761 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 2.67 | uM | 11851.158 | 0.6514 | 0.4794 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 13.3 | uM | 11851.158 | 0.3224 | -0.0980 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 66.7 | uM | 11851.158 | 0.1806 | -0.4000 | 1.4217 |