Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.107 | uM | 10937.153 | 0.9535 | 0.9382 | 1.5187 | |
| HCC3153 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.533 | uM | 10937.153 | 0.9325 | 0.9100 | 1.5187 | |
| HCC3153 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 2.67 | uM | 10937.153 | 0.8755 | 0.8323 | 1.5187 | |
| HCC3153 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 13.3 | uM | 10937.153 | 0.6042 | 0.4353 | 1.5187 | |
| HCC3153 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 66.7 | uM | 10937.153 | 0.0111 | -0.8966 | 1.5187 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.000171 | uM | 10578.141 | 0.8822 | 0.8464 | 1.5679 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.000853 | uM | 10578.141 | 0.8923 | 0.8598 | 1.5679 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.00427 | uM | 10578.141 | 0.9188 | 0.8949 | 1.5679 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.0213 | uM | 10578.141 | 0.9290 | 0.9082 | 1.5679 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.107 | uM | 10578.141 | 0.9759 | 0.9691 | 1.5679 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.533 | uM | 10578.141 | 0.9145 | 0.8891 | 1.5679 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 2.67 | uM | 10578.141 | 0.8727 | 0.8337 | 1.5679 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 13.3 | uM | 10578.141 | 0.7246 | 0.6286 | 1.5679 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 66.7 | uM | 10578.141 | 0.0251 | -0.8095 | 1.5679 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.000171 | uM | 11850.158 | 0.9483 | 0.9472 | 1.9855 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.000853 | uM | 11850.158 | 0.9816 | 0.9814 | 1.9855 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.00427 | uM | 11850.158 | 0.9261 | 0.9241 | 1.9855 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.0213 | uM | 11850.158 | 0.9001 | 0.8967 | 1.9855 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.107 | uM | 11850.158 | 0.9503 | 0.9493 | 1.9855 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 0.533 | uM | 11850.158 | 0.9426 | 0.9413 | 1.9855 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 2.67 | uM | 11850.158 | 0.9380 | 0.9365 | 1.9855 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 13.3 | uM | 11850.158 | 0.4449 | 0.3301 | 1.9855 | |
| HCC38 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 66.7 | uM | 11850.158 | 0.0153 | -0.7560 | 1.9855 | |
| HCC70 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.000171 | uM | 10873.153 | 0.9016 | 0.8511 | 1.3397 | |
| HCC70 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 0.000853 | uM | 10873.153 | 1.0641 | 1.0950 | 1.3397 |