Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | AG1478 | EGFR | ErbB | 6.67 | uM | 7909.016 | 1.0559 | 1.0809 | 1.3701 | |
| MDA-MB-468 | TNBC | Basal A | AG1478 | EGFR | ErbB | 33.3 | uM | 7909.016 | 0.4895 | 0.1874 | 1.3701 | |
| MDA-MB-468 | TNBC | Basal A | AG1478 | EGFR | ErbB | 167 | uM | 7909.016 | 0.1079 | -0.6061 | 1.3701 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 7912.016 | 0.9289 | 0.6873 | 0.4337 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 7912.016 | 1.0277 | 1.1303 | 0.4337 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 7912.016 | 0.9948 | 0.9761 | 0.4337 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7912.016 | 0.8890 | 0.5249 | 0.4337 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.267 | uM | 7912.016 | 0.8865 | 0.5149 | 0.4337 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 1.33 | uM | 7912.016 | 0.8258 | 0.2864 | 0.4337 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 6.67 | uM | 7912.016 | 0.4986 | -0.5981 | 0.4337 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 33.3 | uM | 7912.016 | 0.3466 | -0.8262 | 0.4337 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 167 | uM | 7912.016 | 0.2799 | -0.8938 | 0.4337 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 7914.016 | 0.9192 | 0.8988 | 1.6240 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 7914.016 | 0.9174 | 0.8966 | 1.6240 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 7914.016 | 0.9300 | 0.9126 | 1.6240 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7914.016 | 0.9118 | 0.8895 | 1.6240 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.267 | uM | 7914.016 | 0.9459 | 0.9326 | 1.6240 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 1.33 | uM | 7914.016 | 0.8590 | 0.8213 | 1.6240 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 6.67 | uM | 7914.016 | 0.4808 | 0.2741 | 1.6240 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 33.3 | uM | 7914.016 | 0.0681 | -0.6178 | 1.6240 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 167 | uM | 7914.016 | 0.0763 | -0.5897 | 1.6240 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 9759.019 | 0.9665 | 0.9507 | 1.3677 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 9759.019 | 0.9605 | 0.9419 | 1.3677 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 9759.019 | 0.9363 | 0.9061 | 1.3677 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 9759.019 | 1.0197 | 1.0287 | 1.3677 |