Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7537.067 | 0.9762 | 0.9757 | 1.9773 | |
| SUM229PE | TNBC | - | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7537.067 | 0.9583 | 0.9574 | 1.9773 | |
| SUM229PE | TNBC | - | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7537.067 | 0.9416 | 0.9401 | 1.9773 | |
| SUM229PE | TNBC | - | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7537.067 | 0.9618 | 0.9610 | 1.9773 | |
| SUM229PE | TNBC | - | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7537.067 | 0.6812 | 0.6471 | 1.9773 | |
| SUM229PE | TNBC | - | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7537.067 | 0.4451 | 0.3281 | 1.9773 | |
| SUM229PE | TNBC | - | Purvalanol A | CDK1 | CDK | 167 | uM | 7537.067 | 0.2544 | 0.0008 | 1.9773 | |
| SUM52PE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7541.067 | 0.9522 | 0.9333 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7541.067 | 0.8994 | 0.8586 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7541.067 | 0.9772 | 0.9684 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7541.067 | 0.9288 | 0.9004 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7541.067 | 0.9652 | 0.9515 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7541.067 | 0.9988 | 0.9983 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7541.067 | 0.8355 | 0.7663 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7541.067 | 0.5011 | 0.2402 | 1.4459 | |
| SUM52PE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7541.067 | 0.3777 | 0.0199 | 1.4459 | |
| T47D | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7543.067 | 1.0365 | 1.0586 | 1.2437 | |
| T47D | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7543.067 | 1.0531 | 1.0850 | 1.2437 | |
| T47D | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7543.067 | 0.9837 | 0.9738 | 1.2437 | |
| T47D | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7543.067 | 1.0650 | 1.1039 | 1.2437 | |
| T47D | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7543.067 | 0.9938 | 0.9900 | 1.2437 | |
| T47D | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7543.067 | 1.0146 | 1.0234 | 1.2437 | |
| T47D | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7543.067 | 1.0350 | 1.0561 | 1.2437 | |
| T47D | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7543.067 | 0.9695 | 0.9508 | 1.2437 | |
| T47D | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7543.067 | 0.8091 | 0.6867 | 1.2437 |