Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7504.095 | 1.1754 | 1.1616 | 2.0796 | |
| MDA-MB-231 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7504.095 | 1.1590 | 1.1471 | 2.0796 | |
| MDA-MB-231 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7504.095 | 1.1495 | 1.1386 | 2.0796 | |
| MDA-MB-231 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7504.095 | 1.1883 | 1.1730 | 2.0796 | |
| MDA-MB-231 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7504.095 | 1.0074 | 1.0071 | 2.0796 | |
| MDA-MB-231 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7504.095 | 1.0866 | 1.0815 | 2.0796 | |
| MDA-MB-231 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7504.095 | 0.9424 | 0.9438 | 2.0796 | |
| MDA-MB-231 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7504.095 | 0.9721 | 0.9730 | 2.0796 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7506.095 | 0.8991 | 0.8336 | 1.2246 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7506.095 | 0.9711 | 0.9527 | 1.2246 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7506.095 | 0.8749 | 0.7933 | 1.2246 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7506.095 | 0.6582 | 0.4213 | 1.2246 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7506.095 | 0.5452 | 0.2187 | 1.2246 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7506.095 | 0.5359 | 0.2017 | 1.2246 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7506.095 | 0.5100 | 0.1541 | 1.2246 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7506.095 | 0.5974 | 0.3131 | 1.2246 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7506.095 | 0.7921 | 0.6534 | 1.2246 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7507.094 | 0.5368 | 0.1008 | 1.0418 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7507.094 | 0.9743 | 0.9507 | 1.0418 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7507.094 | 0.9207 | 0.8475 | 1.0418 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7507.094 | 0.6429 | 0.3088 | 1.0418 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7507.094 | 0.5640 | 0.1542 | 1.0418 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7507.094 | 0.5214 | 0.0705 | 1.0418 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7507.094 | 0.5253 | 0.0781 | 1.0418 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7507.094 | 0.5036 | 0.0352 | 1.0418 |