Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7498.095 | 0.8980 | 0.8329 | 1.2329 | |
| MDA-MB-157 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7498.095 | 0.8903 | 0.8200 | 1.2329 | |
| MDA-MB-157 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7498.095 | 0.8516 | 0.7556 | 1.2329 | |
| MDA-MB-157 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7498.095 | 0.8634 | 0.7754 | 1.2329 | |
| MDA-MB-157 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7498.095 | 0.9094 | 0.8517 | 1.2329 | |
| MDA-MB-157 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7498.095 | 0.9751 | 0.9596 | 1.2329 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7499.094 | 1.0034 | 1.0105 | 0.6407 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7499.094 | 1.0035 | 1.0109 | 0.6407 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7499.094 | 1.0413 | 1.1305 | 0.6407 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7499.094 | 1.0149 | 1.0466 | 0.6407 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7499.094 | 0.9714 | 0.9115 | 0.6407 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7499.094 | 0.9999 | 0.9996 | 0.6407 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7499.094 | 1.0191 | 1.0599 | 0.6407 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7499.094 | 1.0186 | 1.0584 | 0.6407 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7499.094 | 1.0253 | 1.0797 | 0.6407 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7500.095 | 1.0834 | 1.3788 | 0.4619 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7500.095 | 1.1958 | 1.9453 | 0.4619 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7500.095 | 0.9806 | 0.9168 | 0.4619 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7500.095 | 1.1776 | 1.8491 | 0.4619 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7500.095 | 1.1311 | 1.6114 | 0.4619 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7500.095 | 1.2218 | 2.0860 | 0.4619 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7500.095 | 1.2034 | 1.9858 | 0.4619 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7500.095 | 1.1416 | 1.6638 | 0.4619 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7500.095 | 1.2884 | 2.4615 | 0.4619 | |
| MDA-MB-231 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7504.095 | 1.1841 | 1.1693 | 2.0796 |