Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7465.095 | 0.9362 | 0.8992 | 1.2754 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7465.095 | 0.9807 | 0.9697 | 1.2754 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7465.095 | 0.9199 | 0.8733 | 1.2754 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7465.095 | 0.8829 | 0.8139 | 1.2754 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7465.095 | 0.9538 | 0.9271 | 1.2754 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7465.095 | 0.8987 | 0.8393 | 1.2754 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7466.095 | 0.9927 | 0.9832 | 0.8699 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7466.095 | 1.0113 | 1.0260 | 0.8699 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7466.095 | 0.9908 | 0.9790 | 0.8699 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7466.095 | 1.0192 | 1.0442 | 0.8699 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7466.095 | 1.0294 | 1.0676 | 0.8699 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7466.095 | 0.9793 | 0.9525 | 0.8699 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7466.095 | 1.0126 | 1.0290 | 0.8699 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7466.095 | 1.0017 | 1.0039 | 0.8699 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7466.095 | 1.0060 | 1.0138 | 0.8699 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7467.095 | 0.9986 | 0.9978 | 1.2671 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7467.095 | 1.0326 | 1.0512 | 1.2671 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7467.095 | 0.8789 | 0.8063 | 1.2671 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7467.095 | 0.7708 | 0.6286 | 1.2671 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7467.095 | 0.7905 | 0.6613 | 1.2671 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7467.095 | 0.7945 | 0.6679 | 1.2671 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7467.095 | 0.7885 | 0.6580 | 1.2671 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7467.095 | 0.8056 | 0.6863 | 1.2671 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7467.095 | 0.7886 | 0.6582 | 1.2671 | |
| HCC38 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7468.095 | 0.9898 | 0.9858 | 1.4474 |