Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7442.095 | 0.8436 | 0.6104 | 0.7851 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7442.095 | 0.8672 | 0.6681 | 0.7851 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7442.095 | 0.8606 | 0.6519 | 0.7851 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7443.094 | 0.9312 | 0.8452 | 0.8852 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7443.094 | 1.0182 | 1.0412 | 0.8852 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7443.094 | 1.0235 | 1.0532 | 0.8852 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7443.094 | 0.9241 | 0.8293 | 0.8852 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7443.094 | 0.9528 | 0.8937 | 0.8852 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7443.094 | 0.8983 | 0.7719 | 0.8852 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7443.094 | 0.8936 | 0.7613 | 0.8852 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7443.094 | 0.8897 | 0.7527 | 0.8852 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7443.094 | 0.9529 | 0.8938 | 0.8852 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7444.095 | 0.9604 | 0.9100 | 0.8776 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7444.095 | 0.9907 | 0.9789 | 0.8776 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7444.095 | 0.9200 | 0.8188 | 0.8776 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7444.095 | 0.8769 | 0.7219 | 0.8776 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7444.095 | 0.7942 | 0.5382 | 0.8776 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7444.095 | 0.8429 | 0.6460 | 0.8776 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7444.095 | 0.8001 | 0.5512 | 0.8776 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7444.095 | 0.8469 | 0.6550 | 0.8776 | |
| HCC1428 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7444.095 | 0.8862 | 0.7429 | 0.8776 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7448.095 | 0.9614 | 0.9731 | 2.9105 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7448.095 | 0.9925 | 0.9948 | 2.9105 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7448.095 | 0.9727 | 0.9811 | 2.9105 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7448.095 | 0.9821 | 0.9876 | 2.9105 |