Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7448.095 | 0.9577 | 0.9705 | 2.9105 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7448.095 | 1.0020 | 1.0014 | 2.9105 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7448.095 | 0.9903 | 0.9933 | 2.9105 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7448.095 | 0.3278 | 0.3634 | 2.9105 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7448.095 | 0.7020 | 0.7711 | 2.9105 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7449.095 | 0.9453 | 0.9449 | 2.0118 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7449.095 | 0.9734 | 0.9733 | 2.0118 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7449.095 | 0.9324 | 0.9316 | 2.0118 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7449.095 | 0.9387 | 0.9380 | 2.0118 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7449.095 | 0.9410 | 0.9404 | 2.0118 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7449.095 | 0.9381 | 0.9374 | 2.0118 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7449.095 | 0.9305 | 0.9297 | 2.0118 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7449.095 | 0.9188 | 0.9175 | 2.0118 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7449.095 | 0.9392 | 0.9386 | 2.0118 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7450.095 | 1.2338 | 1.2499 | 1.7844 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7450.095 | 1.2642 | 1.2808 | 1.7844 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 7450.095 | 1.2546 | 1.2711 | 1.7844 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 7450.095 | 1.2981 | 1.3149 | 1.7844 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 7450.095 | 1.2221 | 1.2380 | 1.7844 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 7450.095 | 1.3082 | 1.3250 | 1.7844 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 7450.095 | 1.3514 | 1.3676 | 1.7844 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 7450.095 | 1.2868 | 1.3036 | 1.7844 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 7450.095 | 1.3030 | 1.3198 | 1.7844 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 7451.095 | 0.7973 | 0.8045 | 2.2028 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 7451.095 | 0.7533 | 0.7587 | 2.2028 |