Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0533 | uM | 11939.155 | 0.9451 | 0.9332 | 1.6625 | |
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0533 | uM | 11939.155 | 0.9451 | 0.9332 | 1.6625 | |
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 0.267 | uM | 11939.155 | 0.8616 | 0.8286 | 1.6625 | |
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 0.267 | uM | 11939.155 | 0.8616 | 0.8286 | 1.6625 | |
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 1.33 | uM | 11939.155 | 1.0126 | 1.0152 | 1.6625 | |
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 1.33 | uM | 11939.155 | 1.0126 | 1.0152 | 1.6625 | |
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 6.67 | uM | 11939.155 | 0.8489 | 0.8123 | 1.6625 | |
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 6.67 | uM | 11939.155 | 0.8489 | 0.8123 | 1.6625 | |
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 33.3 | uM | 11939.155 | 0.8733 | 0.8435 | 1.6625 | |
| ZR75B | HR+ | Luminal | PD184352 | MEK | MAPK | 33.3 | uM | 11939.155 | 0.8733 | 0.8435 | 1.6625 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 5894.095 | 0.9508 | 0.9420 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 5894.095 | 0.9978 | 0.9974 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 5894.095 | 1.0143 | 1.0167 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 5894.095 | 1.0198 | 1.0230 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5894.095 | 0.7840 | 0.7352 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 5894.095 | 0.8199 | 0.7812 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 5894.095 | 0.4918 | 0.3218 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 5894.095 | 0.2174 | -0.1792 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 5894.095 | 0.3330 | 0.0526 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 5895.095 | 1.0112 | 1.0153 | 1.4629 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 5895.095 | 0.9618 | 0.9475 | 1.4629 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 5895.095 | 0.8564 | 0.7989 | 1.4629 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 5895.095 | 0.4631 | 0.1817 | 1.4629 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5895.095 | 0.3652 | 0.0046 | 1.4629 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 5895.095 | 0.3210 | -0.0803 | 1.4629 |