Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | PD184352 | MEK | MAPK | 1.33 | uM | 12098.155 | 0.9435 | 0.8923 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | PD184352 | MEK | MAPK | 6.67 | uM | 12098.155 | 0.8775 | 0.7660 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | PD184352 | MEK | MAPK | 6.67 | uM | 12098.155 | 0.8775 | 0.7660 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | PD184352 | MEK | MAPK | 33.3 | uM | 12098.155 | 0.8639 | 0.7400 | 1.0503 | |
| SUM225CWN | HER2amp | Basal A | PD184352 | MEK | MAPK | 33.3 | uM | 12098.155 | 0.8639 | 0.7400 | 1.0503 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.0000853 | uM | 11058.155 | 0.9432 | 0.9443 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.0000853 | uM | 11058.155 | 0.9432 | 0.9443 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.000427 | uM | 11058.155 | 1.0448 | 1.0428 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.000427 | uM | 11058.155 | 1.0448 | 1.0428 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.00213 | uM | 11058.155 | 0.9473 | 0.9484 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.00213 | uM | 11058.155 | 0.9473 | 0.9484 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.0107 | uM | 11058.155 | 0.9511 | 0.9522 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.0107 | uM | 11058.155 | 0.9511 | 0.9522 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.0533 | uM | 11058.155 | 0.9090 | 0.9100 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.0533 | uM | 11058.155 | 0.9090 | 0.9100 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.267 | uM | 11058.155 | 0.6453 | 0.6187 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 0.267 | uM | 11058.155 | 0.6453 | 0.6187 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 1.33 | uM | 11058.155 | 0.5022 | 0.4340 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 1.33 | uM | 11058.155 | 0.5022 | 0.4340 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 6.67 | uM | 11058.155 | 0.3423 | 0.1917 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 6.67 | uM | 11058.155 | 0.3423 | 0.1917 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 33.3 | uM | 11058.155 | 0.2134 | -0.0515 | 2.0706 | |
| SUM229PE | TNBC | - | PD184352 | MEK | MAPK | 33.3 | uM | 11058.155 | 0.2134 | -0.0515 | 2.0706 | |
| SUM52PE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.000171 | uM | 10695.146 | 0.9439 | 0.9201 | 1.4179 | |
| SUM52PE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.000171 | uM | 10695.146 | 0.9439 | 0.9201 | 1.4179 |