Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | PD184352 | MEK | MAPK | 1.33 | uM | 12126.155 | 0.9427 | 0.8337 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | PD184352 | MEK | MAPK | 1.33 | uM | 12126.155 | 0.9427 | 0.8337 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | PD184352 | MEK | MAPK | 6.67 | uM | 12126.155 | 0.8916 | 0.6895 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | PD184352 | MEK | MAPK | 6.67 | uM | 12126.155 | 0.8916 | 0.6895 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | PD184352 | MEK | MAPK | 33.3 | uM | 12126.155 | 0.8785 | 0.6531 | 0.6799 | |
| MDA-MB-175-VII | HR+ | Luminal | PD184352 | MEK | MAPK | 33.3 | uM | 12126.155 | 0.8785 | 0.6531 | 0.6799 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.000171 | uM | 10643.146 | 0.9592 | 0.8747 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.000171 | uM | 10643.146 | 0.9592 | 0.8747 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.000853 | uM | 10643.146 | 1.0105 | 1.0327 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.000853 | uM | 10643.146 | 1.0105 | 1.0327 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.00427 | uM | 10643.146 | 1.0174 | 1.0544 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.00427 | uM | 10643.146 | 1.0174 | 1.0544 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.0213 | uM | 10643.146 | 1.0186 | 1.0579 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.0213 | uM | 10643.146 | 1.0186 | 1.0579 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.107 | uM | 10643.146 | 1.0165 | 1.0516 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.107 | uM | 10643.146 | 1.0165 | 1.0516 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.533 | uM | 10643.146 | 0.9696 | 0.9063 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.533 | uM | 10643.146 | 0.9696 | 0.9063 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 2.67 | uM | 10643.146 | 1.0162 | 1.0506 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 2.67 | uM | 10643.146 | 1.0162 | 1.0506 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 13.3 | uM | 10643.146 | 0.9256 | 0.7735 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 13.3 | uM | 10643.146 | 0.9256 | 0.7735 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 66.7 | uM | 10643.146 | 1.0131 | 1.0408 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 66.7 | uM | 10643.146 | 1.0131 | 1.0408 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 10999.155 | 1.0235 | 1.0641 | 0.7370 |