Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 66.7 | uM | 7431.1 | 0.0087 | -0.9046 | 1.5594 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 0.000171 | uM | 10518.1 | 1.0683 | 1.0963 | 1.4056 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 0.000853 | uM | 10518.1 | 0.9140 | 0.8760 | 1.4056 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 0.00427 | uM | 10518.1 | 0.9322 | 0.9025 | 1.4056 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 0.0213 | uM | 10518.1 | 0.9047 | 0.8625 | 1.4056 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 0.107 | uM | 10518.1 | 0.9663 | 0.9518 | 1.4056 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 0.533 | uM | 10518.1 | 0.8592 | 0.7954 | 1.4056 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 2.67 | uM | 10518.1 | 0.9356 | 0.9074 | 1.4056 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 13.3 | uM | 10518.1 | 0.5983 | 0.3877 | 1.4056 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 66.7 | uM | 10518.1 | 0.0058 | -0.9484 | 1.4056 | |
| HCC1395 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 7436.093 | 1.0266 | 1.0421 | 1.2596 | |
| HCC1395 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 7436.093 | 1.0131 | 1.0207 | 1.2596 | |
| HCC1395 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 7436.093 | 0.9927 | 0.9885 | 1.2596 | |
| HCC1395 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 7436.093 | 0.9466 | 0.9147 | 1.2596 | |
| HCC1395 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 7436.093 | 0.8786 | 0.8046 | 1.2596 | |
| HCC1395 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 7436.093 | 0.7337 | 0.5641 | 1.2596 | |
| HCC1395 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 1.33 | uM | 7436.093 | 0.6404 | 0.4041 | 1.2596 | |
| HCC1395 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 6.67 | uM | 7436.093 | 0.4388 | 0.0399 | 1.2596 | |
| HCC1395 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 33.3 | uM | 7436.093 | 0.0744 | -0.7459 | 1.2596 | |
| HCC1419 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 7437.093 | 0.9983 | 0.9926 | 0.4731 | |
| HCC1419 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 7437.093 | 1.0373 | 1.1609 | 0.4731 | |
| HCC1419 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 7437.093 | 0.9806 | 0.9189 | 0.4731 | |
| HCC1419 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 7437.093 | 0.9543 | 0.8117 | 0.4731 | |
| HCC1419 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 7437.093 | 0.9850 | 0.9370 | 0.4731 | |
| HCC1419 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 7437.093 | 0.9308 | 0.7185 | 0.4731 |