Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 10385.093 | 1.0285 | 1.0946 | 0.6082 | |
| BT-20 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 10385.093 | 0.9852 | 0.9516 | 0.6082 | |
| BT-20 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 10385.093 | 1.0995 | 1.3376 | 0.6082 | |
| BT-20 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 1.33 | uM | 10385.093 | 1.0818 | 1.2760 | 0.6082 | |
| BT-20 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 6.67 | uM | 10385.093 | 0.8922 | 0.6580 | 0.6082 | |
| BT-20 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 33.3 | uM | 10385.093 | 0.3704 | -0.6094 | 0.6082 | |
| BT-474 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 5905.093 | 1.0344 | 1.0757 | 0.9101 | |
| BT-474 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 5905.093 | 1.0678 | 1.1494 | 0.9101 | |
| BT-474 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 5905.093 | 0.9968 | 0.9929 | 0.9101 | |
| BT-474 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 5905.093 | 1.0623 | 1.1373 | 0.9101 | |
| BT-474 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 5905.093 | 1.0145 | 1.0319 | 0.9101 | |
| BT-474 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 5905.093 | 0.9937 | 0.9861 | 0.9101 | |
| BT-474 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 1.33 | uM | 5905.093 | 1.0513 | 1.1131 | 0.9101 | |
| BT-474 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 6.67 | uM | 5905.093 | 0.9606 | 0.9135 | 0.9101 | |
| BT-474 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 33.3 | uM | 5905.093 | 0.1626 | -0.7281 | 0.9101 | |
| BT-549 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 5909.093 | 1.0743 | 1.0504 | 2.8805 | |
| BT-549 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 5909.093 | 1.0653 | 1.0444 | 2.8805 | |
| BT-549 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 5909.093 | 1.0878 | 1.0593 | 2.8805 | |
| BT-549 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 5909.093 | 1.0575 | 1.0392 | 2.8805 | |
| BT-549 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 5909.093 | 1.0786 | 1.0532 | 2.8805 | |
| BT-549 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 5909.093 | 1.0198 | 1.0137 | 2.8805 | |
| BT-549 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 1.33 | uM | 5909.093 | 0.9204 | 0.9432 | 2.8805 | |
| BT-549 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 6.67 | uM | 5909.093 | 0.6303 | 0.7039 | 2.8805 | |
| BT-549 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 33.3 | uM | 5909.093 | 0.0014 | -0.7946 | 2.8805 | |
| CAMA-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.000171 | uM | 10473.1 | 0.9807 | 0.9716 | 1.3652 |