Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.16 | uM | 11852.159 | 1.0107 | 1.0161 | 1.3247 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.8 | uM | 11852.159 | 0.9016 | 0.8495 | 1.3247 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 4 | uM | 11852.159 | 0.9285 | 0.8911 | 1.3247 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 20 | uM | 11852.159 | 0.5437 | 0.2626 | 1.3247 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 100 | uM | 11852.159 | 0.4501 | 0.0947 | 1.3247 | |
| T47D | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000128 | uM | 10939.152 | 0.9269 | 0.9124 | 1.6952 | |
| T47D | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00064 | uM | 10939.152 | 0.9608 | 0.9534 | 1.6952 | |
| T47D | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0032 | uM | 10939.152 | 0.9585 | 0.9507 | 1.6952 | |
| T47D | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.016 | uM | 10939.152 | 0.9416 | 0.9303 | 1.6952 | |
| T47D | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.08 | uM | 10939.152 | 0.9519 | 0.9427 | 1.6952 | |
| T47D | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.4 | uM | 10939.152 | 0.9701 | 0.9646 | 1.6952 | |
| T47D | HR+ | Luminal | PD 98059 | MEK | MAPK | 2 | uM | 10939.152 | 0.9797 | 0.9760 | 1.6952 | |
| T47D | HR+ | Luminal | PD 98059 | MEK | MAPK | 10 | uM | 10939.152 | 0.9786 | 0.9747 | 1.6952 | |
| T47D | HR+ | Luminal | PD 98059 | MEK | MAPK | 50 | uM | 10939.152 | 0.9157 | 0.8987 | 1.6952 | |
| T47DKBLUC | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.000128 | uM | 12608.152 | 0.9479 | 0.9089 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.00064 | uM | 12608.152 | 0.9537 | 0.9191 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.0032 | uM | 12608.152 | 0.9813 | 0.9673 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.016 | uM | 12608.152 | 0.9717 | 0.9506 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.08 | uM | 12608.152 | 0.9689 | 0.9457 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.4 | uM | 12608.152 | 0.9532 | 0.9183 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | PD 98059 | MEK | MAPK | 2 | uM | 12608.152 | 1.0004 | 1.0008 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | PD 98059 | MEK | MAPK | 10 | uM | 12608.152 | 0.9538 | 0.9193 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | PD 98059 | MEK | MAPK | 50 | uM | 12608.152 | 1.0074 | 1.0129 | 1.1477 | |
| UACC-812 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.000256 | uM | 10580.136 | 0.9537 | 0.8727 | 0.7205 | |
| UACC-812 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.00128 | uM | 10580.136 | 0.9534 | 0.8719 | 0.7205 |