Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 4 | uM | 10519.136 | 0.9804 | 0.9655 | 1.1406 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 20 | uM | 10519.136 | 0.9390 | 0.8926 | 1.1406 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 100 | uM | 10519.136 | 0.7555 | 0.5642 | 1.1406 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000128 | uM | 10998.152 | 0.9590 | 0.9041 | 0.8517 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00064 | uM | 10998.152 | 0.9092 | 0.7885 | 0.8517 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0032 | uM | 10998.152 | 0.9409 | 0.8619 | 0.8517 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.016 | uM | 10998.152 | 0.9658 | 0.9200 | 0.8517 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.08 | uM | 10998.152 | 0.9968 | 0.9925 | 0.8517 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.4 | uM | 10998.152 | 0.9625 | 0.9123 | 0.8517 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 2 | uM | 10998.152 | 1.0982 | 1.2326 | 0.8517 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 10 | uM | 10998.152 | 1.0121 | 1.0283 | 0.8517 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 50 | uM | 10998.152 | 0.8871 | 0.7376 | 0.8517 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000256 | uM | 12206.159 | 0.9459 | 0.8991 | 1.0742 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00128 | uM | 12206.159 | 0.8729 | 0.7623 | 1.0742 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0064 | uM | 12206.159 | 0.9029 | 0.8185 | 1.0742 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.032 | uM | 12206.159 | 0.9316 | 0.8724 | 1.0742 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.16 | uM | 12206.159 | 0.8922 | 0.7986 | 1.0742 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.8 | uM | 12206.159 | 0.9564 | 0.9186 | 1.0742 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 4 | uM | 12206.159 | 1.0288 | 1.0535 | 1.0742 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 20 | uM | 12206.159 | 0.9083 | 0.8287 | 1.0742 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 100 | uM | 12206.159 | 0.7455 | 0.5216 | 1.0742 | |
| MDA-MB-157 | TNBC | Basal B | PD 98059 | MEK | MAPK | 0.000128 | uM | 12594.152 | 1.0039 | 1.0059 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | PD 98059 | MEK | MAPK | 0.00064 | uM | 12594.152 | 1.0468 | 1.0712 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | PD 98059 | MEK | MAPK | 0.0032 | uM | 12594.152 | 0.9883 | 0.9821 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | PD 98059 | MEK | MAPK | 0.016 | uM | 12594.152 | 1.0451 | 1.0686 | 1.3085 |