Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Oxamflatin | HDAC | HDAC | 66.7 | uM | 10817.147 | 0.0141 | -0.8823 | 1.5041 | |
| MCF12A | NM | Basal B | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 12365.147 | 0.9467 | 0.9412 | 1.8376 | |
| MCF12A | NM | Basal B | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 12365.147 | 0.8674 | 0.8511 | 1.8376 | |
| MCF12A | NM | Basal B | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 12365.147 | 1.3017 | 1.3086 | 1.8376 | |
| MCF12A | NM | Basal B | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 12365.147 | 1.2745 | 1.2822 | 1.8376 | |
| MCF12A | NM | Basal B | Oxamflatin | HDAC | HDAC | 0.107 | uM | 12365.147 | 1.1744 | 1.1829 | 1.8376 | |
| MCF12A | NM | Basal B | Oxamflatin | HDAC | HDAC | 0.533 | uM | 12365.147 | 0.8498 | 0.8305 | 1.8376 | |
| MCF12A | NM | Basal B | Oxamflatin | HDAC | HDAC | 2.67 | uM | 12365.147 | 0.4877 | 0.3530 | 1.8376 | |
| MCF12A | NM | Basal B | Oxamflatin | HDAC | HDAC | 13.3 | uM | 12365.147 | 0.2108 | -0.1429 | 1.8376 | |
| MCF12A | NM | Basal B | Oxamflatin | HDAC | HDAC | 66.7 | uM | 12365.147 | 0.0072 | -0.8632 | 1.8376 | |
| MCF7 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 10997.147 | 0.9891 | 0.9842 | 1.3792 | |
| MCF7 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 10997.147 | 0.9459 | 0.9209 | 1.3792 | |
| MCF7 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 10997.147 | 0.9449 | 0.9195 | 1.3792 | |
| MCF7 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 10997.147 | 0.9849 | 0.9780 | 1.3792 | |
| MCF7 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.107 | uM | 10997.147 | 0.9767 | 0.9661 | 1.3792 | |
| MCF7 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.533 | uM | 10997.147 | 0.8287 | 0.7452 | 1.3792 | |
| MCF7 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 2.67 | uM | 10997.147 | 0.6166 | 0.4086 | 1.3792 | |
| MCF7 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 13.3 | uM | 10997.147 | 0.1170 | -0.5780 | 1.3792 | |
| MCF7 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 66.7 | uM | 10997.147 | 0.1351 | -0.5316 | 1.3792 | |
| MDA-MB-134-VI | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 10998.147 | 1.0014 | 1.0032 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 10998.147 | 0.9944 | 0.9870 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 10998.147 | 0.9418 | 0.8648 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 10998.147 | 0.9421 | 0.8655 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.107 | uM | 10998.147 | 0.9280 | 0.8330 | 0.8573 | |
| MDA-MB-134-VI | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.533 | uM | 10998.147 | 0.8023 | 0.5469 | 0.8573 |