Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.533 | uM | 10873.147 | 0.7454 | 0.5945 | 1.2965 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 2.67 | uM | 10873.147 | 0.2336 | -0.3484 | 1.2965 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 13.3 | uM | 10873.147 | 0.0129 | -0.9302 | 1.2965 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 66.7 | uM | 10873.147 | 0.0093 | -0.9458 | 1.2965 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 12400.147 | 0.9977 | 0.9963 | 1.2599 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 12400.147 | 0.9981 | 0.9969 | 1.2599 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 12400.147 | 0.9495 | 0.9195 | 1.2599 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 12400.147 | 0.9253 | 0.8805 | 1.2599 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.107 | uM | 12400.147 | 0.8820 | 0.8103 | 1.2599 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.533 | uM | 12400.147 | 0.6012 | 0.3355 | 1.2599 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 2.67 | uM | 12400.147 | 0.1009 | -0.6761 | 1.2599 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 13.3 | uM | 12400.147 | 0.0101 | -0.9479 | 1.2599 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 66.7 | uM | 12400.147 | 0.0108 | -0.9449 | 1.2599 | |
| Hs 578T | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 10694.147 | 0.9823 | 0.9850 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 10694.147 | 0.9950 | 0.9958 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 10694.147 | 1.0095 | 1.0080 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 10694.147 | 0.9828 | 0.9855 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.107 | uM | 10694.147 | 0.9900 | 0.9916 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.533 | uM | 10694.147 | 0.8448 | 0.8633 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 2.67 | uM | 10694.147 | 0.3241 | 0.2462 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 13.3 | uM | 10694.147 | 0.0598 | -0.3872 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 66.7 | uM | 10694.147 | 0.0160 | -0.6479 | 2.3818 | |
| LY2 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 10816.147 | 1.1626 | 1.4596 | 0.7283 | |
| LY2 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 10816.147 | 1.0705 | 1.1961 | 0.7283 | |
| LY2 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 10816.147 | 1.0216 | 1.0595 | 0.7283 |