Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 66.7 | uM | 12070.147 | 0.0110 | -0.9845 | 0.9269 | |
| HCC1143 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 12112.147 | 0.8588 | 0.8425 | 1.8559 | |
| HCC1143 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 12112.147 | 0.9418 | 0.9364 | 1.8559 | |
| HCC1143 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 12112.147 | 0.9516 | 0.9472 | 1.8559 | |
| HCC1143 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 12112.147 | 0.9790 | 0.9772 | 1.8559 | |
| HCC1143 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.107 | uM | 12112.147 | 0.7861 | 0.7567 | 1.8559 | |
| HCC1143 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.533 | uM | 12112.147 | 0.6513 | 0.5875 | 1.8559 | |
| HCC1143 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 2.67 | uM | 12112.147 | 0.2621 | -0.0280 | 1.8559 | |
| HCC1143 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 13.3 | uM | 12112.147 | 0.0705 | -0.5208 | 1.8559 | |
| HCC1143 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 66.7 | uM | 12112.147 | 0.0290 | -0.7033 | 1.8559 | |
| HCC1187 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 10753.147 | 1.0616 | 1.0980 | 1.2493 | |
| HCC1187 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 10753.147 | 0.9431 | 0.9084 | 1.2493 | |
| HCC1187 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 10753.147 | 0.9706 | 0.9528 | 1.2493 | |
| HCC1187 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 10753.147 | 0.9697 | 0.9514 | 1.2493 | |
| HCC1187 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.107 | uM | 10753.147 | 1.0236 | 1.0377 | 1.2493 | |
| HCC1187 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.533 | uM | 10753.147 | 0.7189 | 0.5356 | 1.2493 | |
| HCC1187 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 2.67 | uM | 10753.147 | 0.2686 | -0.3017 | 1.2493 | |
| HCC1187 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 13.3 | uM | 10753.147 | 0.0271 | -0.8887 | 1.2493 | |
| HCC1187 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 66.7 | uM | 10753.147 | 0.0095 | -0.9518 | 1.2493 | |
| HCC1395 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 12000.147 | 0.9377 | 0.8568 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 12000.147 | 0.8898 | 0.7477 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 12000.147 | 0.9463 | 0.8765 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 12000.147 | 0.9217 | 0.8202 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.107 | uM | 12000.147 | 0.9168 | 0.8090 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.533 | uM | 12000.147 | 0.9662 | 0.9222 | 0.8658 |