Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 12291.147 | 0.9740 | 0.9138 | 0.5980 | |
| BT-474 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 0.107 | uM | 12291.147 | 0.8116 | 0.4108 | 0.5980 | |
| BT-474 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 0.533 | uM | 12291.147 | 0.7816 | 0.3245 | 0.5980 | |
| BT-474 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 2.67 | uM | 12291.147 | 0.3320 | -0.6835 | 0.5980 | |
| BT-474 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 13.3 | uM | 12291.147 | 0.0665 | -0.9785 | 0.5980 | |
| BT-474 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 66.7 | uM | 12291.147 | 0.0601 | -0.9819 | 0.5980 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 10696.147 | 0.9511 | 0.8002 | 0.4763 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 10696.147 | 0.9470 | 0.7841 | 0.4763 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 10696.147 | 0.9168 | 0.6667 | 0.4763 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 10696.147 | 0.9125 | 0.6501 | 0.4763 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.107 | uM | 10696.147 | 0.9231 | 0.6908 | 0.4763 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.533 | uM | 10696.147 | 0.8365 | 0.3747 | 0.4763 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 2.67 | uM | 10696.147 | 0.5756 | -0.3727 | 0.4763 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 13.3 | uM | 10696.147 | 0.3117 | -0.8270 | 0.4763 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 66.7 | uM | 10696.147 | 0.0565 | -0.9952 | 0.4763 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 11855.147 | 0.9448 | 0.8108 | 0.5719 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 11855.147 | 0.8779 | 0.5927 | 0.5719 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 11855.147 | 0.9671 | 0.8864 | 0.5719 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 11855.147 | 0.9252 | 0.7459 | 0.5719 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.107 | uM | 11855.147 | 0.9133 | 0.7066 | 0.5719 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 0.533 | uM | 11855.147 | 0.9099 | 0.6955 | 0.5719 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 2.67 | uM | 11855.147 | 0.7294 | 0.1519 | 0.5719 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 13.3 | uM | 11855.147 | 0.3606 | -0.6639 | 0.5719 | |
| BT-483 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 66.7 | uM | 11855.147 | 0.0894 | -0.9707 | 0.5719 | |
| BT-549 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 12305.147 | 0.9577 | 0.9703 | 2.8865 |