Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 10420.066 | 0.9728 | 0.8976 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 10420.066 | 1.0008 | 1.0030 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 10420.066 | 0.9977 | 0.9914 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 10420.066 | 1.0353 | 1.1371 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 10420.066 | 0.9599 | 0.8496 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 10420.066 | 0.9368 | 0.7656 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 10420.066 | 0.9868 | 0.9501 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 10420.066 | 0.9463 | 0.8001 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 10420.066 | 0.9429 | 0.7876 | 0.5240 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7552.066 | 0.9955 | 0.9912 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7552.066 | 0.9324 | 0.8671 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7552.066 | 0.9966 | 0.9934 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7552.066 | 1.0106 | 1.0209 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7552.066 | 0.9678 | 0.9367 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 7552.066 | 0.9195 | 0.8417 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 7552.066 | 0.9692 | 0.9395 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7552.066 | 0.9507 | 0.9031 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7552.066 | 0.7305 | 0.4691 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7553.066 | 0.9906 | 0.9806 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7553.066 | 0.9195 | 0.8344 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7553.066 | 1.0107 | 1.0221 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7553.066 | 0.9404 | 0.8773 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7553.066 | 0.9581 | 0.9138 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 7553.066 | 0.9287 | 0.8532 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 7553.066 | 0.9597 | 0.9170 | 0.9707 |