Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10444.087 | 0.9666 | 0.9200 | 0.8325 | |
| ZR-75-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10444.087 | 0.7806 | 0.4852 | 0.8325 | |
| ZR-75-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10444.087 | 0.4362 | -0.2617 | 0.8325 | |
| ZR-75-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 10444.087 | 0.2497 | -0.6223 | 0.8325 | |
| ZR-75-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 10444.087 | 0.2043 | -0.7031 | 0.8325 | |
| ZR-75-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 10444.087 | 0.1624 | -0.7747 | 0.8325 | |
| ZR-75-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 10444.087 | 0.1226 | -0.8393 | 0.8325 | |
| ZR75B | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7555.086 | 1.0145 | 1.0177 | 1.6344 | |
| ZR75B | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7555.086 | 0.8764 | 0.8448 | 1.6344 | |
| ZR75B | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7555.086 | 0.8094 | 0.7573 | 1.6344 | |
| ZR75B | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7555.086 | 0.5133 | 0.3299 | 1.6344 | |
| ZR75B | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7555.086 | 0.3012 | -0.0403 | 1.6344 | |
| ZR75B | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 7555.086 | 0.2116 | -0.2267 | 1.6344 | |
| ZR75B | HR+ | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 7555.086 | 0.1992 | -0.2547 | 1.6344 | |
| ZR75B | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 7555.086 | 0.1971 | -0.2595 | 1.6344 | |
| ZR75B | HR+ | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 7555.086 | 0.2145 | -0.2204 | 1.6344 | |
| 184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00161 | uM | 9047.011 | 1.0010 | 1.0030 | 0.6293 | |
| 184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00805 | uM | 9047.011 | 0.9858 | 0.9552 | 0.6293 | |
| 184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.0403 | uM | 9047.011 | 0.9905 | 0.9697 | 0.6293 | |
| 184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.201 | uM | 9047.011 | 0.8975 | 0.6841 | 0.6293 | |
| 184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 1.01 | uM | 9047.011 | 0.7461 | 0.2556 | 0.6293 | |
| 184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 5.03 | uM | 9047.011 | 0.5645 | -0.1938 | 0.6293 | |
| 184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 25.2 | uM | 9047.011 | 0.1673 | -0.8833 | 0.6293 | |
| 184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 126 | uM | 9047.011 | 0.1522 | -0.8996 | 0.6293 | |
| 184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 629 | uM | 9047.011 | 0.0047 | -0.9996 | 0.6293 |