Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 33.3 | uM | 10518.087 | 0.0779 | -0.7747 | 1.1688 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10753.087 | 0.9856 | 0.9795 | 1.4150 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10753.087 | 0.8893 | 0.8408 | 1.4150 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10753.087 | 0.8431 | 0.7728 | 1.4150 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10753.087 | 0.5880 | 0.3742 | 1.4150 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10753.087 | 0.3786 | 0.0069 | 1.4150 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.267 | uM | 10753.087 | 0.3313 | -0.0838 | 1.4150 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 1.33 | uM | 10753.087 | 0.3212 | -0.1036 | 1.4150 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 6.67 | uM | 10753.087 | 0.1095 | -0.5810 | 1.4150 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 33.3 | uM | 10753.087 | 0.0529 | -0.7496 | 1.4150 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7435.086 | 1.0883 | 1.2236 | 0.7985 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7435.086 | 1.0016 | 1.0039 | 0.7985 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7435.086 | 1.0092 | 1.0230 | 0.7985 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7435.086 | 0.9368 | 0.8430 | 0.7985 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7435.086 | 0.7760 | 0.4557 | 0.7985 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.267 | uM | 7435.086 | 0.5161 | -0.1265 | 0.7985 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 1.33 | uM | 7435.086 | 0.4133 | -0.3387 | 0.7985 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 6.67 | uM | 7435.086 | 0.3885 | -0.3880 | 0.7985 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 33.3 | uM | 7435.086 | 0.3021 | -0.5533 | 0.7985 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7436.086 | 1.0713 | 1.1096 | 1.2908 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7436.086 | 0.9820 | 0.9720 | 1.2908 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7436.086 | 0.9992 | 0.9987 | 1.2908 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7436.086 | 0.8938 | 0.8334 | 1.2908 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7436.086 | 0.6882 | 0.4973 | 1.2908 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.267 | uM | 7436.086 | 0.4160 | 0.0137 | 1.2908 |