Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 1.33 | uM | 7436.086 | 0.3603 | -0.0931 | 1.2908 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 6.67 | uM | 7436.086 | 0.2657 | -0.2837 | 1.2908 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 33.3 | uM | 7436.086 | 0.1951 | -0.4362 | 1.2908 | |
| HCC1419 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7437.086 | 1.0041 | 1.0200 | 0.4150 | |
| HCC1419 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7437.086 | 0.9324 | 0.6896 | 0.4150 | |
| HCC1419 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7437.086 | 0.9086 | 0.5875 | 0.4150 | |
| HCC1419 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7437.086 | 0.6608 | -0.2632 | 0.4150 | |
| HCC1419 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7437.086 | 0.4683 | -0.6787 | 0.4150 | |
| HCC1419 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 7437.086 | 0.3597 | -0.8298 | 0.4150 | |
| HCC1419 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 7437.086 | 0.4166 | -0.7575 | 0.4150 | |
| HCC1419 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 7437.086 | 0.3423 | -0.8490 | 0.4150 | |
| HCC1419 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 7437.086 | 0.1511 | -0.9790 | 0.4150 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7442.087 | 0.9807 | 0.9564 | 0.8842 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7442.087 | 0.9206 | 0.8214 | 0.8842 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7442.087 | 0.9262 | 0.8340 | 0.8842 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7442.087 | 0.8263 | 0.6117 | 0.8842 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7442.087 | 0.6842 | 0.3020 | 0.8842 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 7442.087 | 0.3969 | -0.2968 | 0.8842 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 7442.087 | 0.3711 | -0.3482 | 0.8842 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 7442.087 | 0.3809 | -0.3286 | 0.8842 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 7442.087 | 0.1160 | -0.8250 | 0.8842 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10441.087 | 1.0538 | 1.1092 | 0.9863 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10441.087 | 1.0441 | 1.0894 | 0.9863 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10441.087 | 1.0137 | 1.0277 | 0.9863 | |
| HCC1428 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10441.087 | 0.9147 | 0.8271 | 0.9863 |