Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | PD 98059 | MEK | MAPK | 4 | uM | 12084.159 | 0.9607 | 0.9358 | 1.2294 | |
| HCC1395 | TNBC | Basal B | PD 98059 | MEK | MAPK | 20 | uM | 12084.159 | 0.8518 | 0.7553 | 1.2294 | |
| HCC1395 | TNBC | Basal B | PD 98059 | MEK | MAPK | 100 | uM | 12084.159 | 0.8560 | 0.7624 | 1.2294 | |
| HCC1419 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.000256 | uM | 12001.159 | 0.8820 | 0.6762 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.00128 | uM | 12001.159 | 0.9182 | 0.7736 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.0064 | uM | 12001.159 | 0.9389 | 0.8303 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.032 | uM | 12001.159 | 0.8880 | 0.6922 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.16 | uM | 12001.159 | 0.9408 | 0.8354 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 0.8 | uM | 12001.159 | 0.9092 | 0.7493 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 4 | uM | 12001.159 | 0.8722 | 0.6500 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 20 | uM | 12001.159 | 0.8671 | 0.6364 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 100 | uM | 12001.159 | 0.7775 | 0.4036 | 0.7107 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000128 | uM | 10693.152 | 0.9718 | 0.9355 | 0.8734 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00064 | uM | 10693.152 | 0.9262 | 0.8319 | 0.8734 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0032 | uM | 10693.152 | 0.9787 | 0.9513 | 0.8734 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.016 | uM | 10693.152 | 0.9778 | 0.9492 | 0.8734 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.08 | uM | 10693.152 | 0.9929 | 0.9837 | 0.8734 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.4 | uM | 10693.152 | 0.9241 | 0.8272 | 0.8734 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 2 | uM | 10693.152 | 0.9775 | 0.9485 | 0.8734 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 10 | uM | 10693.152 | 0.9276 | 0.8352 | 0.8734 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 50 | uM | 10693.152 | 0.8734 | 0.7130 | 0.8734 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000256 | uM | 11936.159 | 0.9265 | 0.8058 | 0.7472 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00128 | uM | 11936.159 | 0.9299 | 0.8147 | 0.7472 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0064 | uM | 11936.159 | 0.9762 | 0.9366 | 0.7472 | |
| HCC1428 | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.032 | uM | 11936.159 | 0.9848 | 0.9593 | 0.7472 |