Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 11849.147 | 0.9923 | 0.9886 | 1.3461 | |
| HCC1937 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 11849.147 | 1.0218 | 1.0323 | 1.3461 | |
| HCC1937 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 11849.147 | 0.9827 | 0.9742 | 1.3461 | |
| HCC1937 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 11849.147 | 1.1059 | 1.1553 | 1.3461 | |
| HCC1937 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 0.213 | uM | 11849.147 | 1.0465 | 1.0687 | 1.3461 | |
| HCC1937 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 1.07 | uM | 11849.147 | 1.0553 | 1.0815 | 1.3461 | |
| HCC1937 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 5.33 | uM | 11849.147 | 0.8939 | 0.8401 | 1.3461 | |
| HCC1937 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 26.7 | uM | 11849.147 | 0.2702 | -0.2435 | 1.3461 | |
| HCC1937 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 133 | uM | 11849.147 | 0.2595 | -0.2658 | 1.3461 | |
| HCC1954 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 11055.147 | 0.9987 | 0.9985 | 1.6841 | |
| HCC1954 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 11055.147 | 0.9077 | 0.8883 | 1.6841 | |
| HCC1954 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 11055.147 | 0.9825 | 0.9791 | 1.6841 | |
| HCC1954 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 11055.147 | 1.0347 | 1.0410 | 1.6841 | |
| HCC1954 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 0.213 | uM | 11055.147 | 1.0162 | 1.0192 | 1.6841 | |
| HCC1954 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 1.07 | uM | 11055.147 | 0.9683 | 0.9621 | 1.6841 | |
| HCC1954 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 5.33 | uM | 11055.147 | 0.9007 | 0.8796 | 1.6841 | |
| HCC1954 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 26.7 | uM | 11055.147 | 0.2604 | -0.1003 | 1.6841 | |
| HCC1954 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 133 | uM | 11055.147 | 0.2393 | -0.1445 | 1.6841 | |
| HCC2185 | TNBC | Luminal | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 10996.147 | 0.9541 | 0.8554 | 0.6261 | |
| HCC2185 | TNBC | Luminal | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 10996.147 | 1.0382 | 1.1233 | 0.6261 | |
| HCC2185 | TNBC | Luminal | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 10996.147 | 1.0035 | 1.0110 | 0.6261 | |
| HCC2185 | TNBC | Luminal | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 10996.147 | 1.0694 | 1.2262 | 0.6261 | |
| HCC2185 | TNBC | Luminal | Olomoucine II | CDK1 | CDK | 0.213 | uM | 10996.147 | 0.9951 | 0.9844 | 0.6261 | |
| HCC2185 | TNBC | Luminal | Olomoucine II | CDK1 | CDK | 1.07 | uM | 10996.147 | 1.0070 | 1.0224 | 0.6261 | |
| HCC2185 | TNBC | Luminal | Olomoucine II | CDK1 | CDK | 5.33 | uM | 10996.147 | 0.8973 | 0.6822 | 0.6261 |