Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7532.066 | 1.0176 | 1.0391 | 0.9011 | |
| SUM185PE | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7532.066 | 0.9535 | 0.8971 | 0.9011 | |
| SUM185PE | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7532.066 | 0.9740 | 0.9424 | 0.9011 | |
| SUM185PE | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7532.066 | 0.8785 | 0.7321 | 0.9011 | |
| SUM185PE | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7532.066 | 0.9194 | 0.8218 | 0.9011 | |
| SUM185PE | TNBC | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7532.066 | 0.4062 | -0.2640 | 0.9011 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7533.066 | 0.9605 | 0.9092 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7533.066 | 1.0161 | 1.0373 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7533.066 | 0.9791 | 0.9519 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7533.066 | 0.9839 | 0.9630 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7533.066 | 1.0046 | 1.0106 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7533.066 | 0.9751 | 0.9427 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7533.066 | 0.9408 | 0.8641 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7533.066 | 0.8608 | 0.6825 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7533.066 | 0.0420 | -0.9482 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7534.066 | 0.9827 | 0.9661 | 1.0191 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7534.066 | 0.9895 | 0.9795 | 1.0191 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7534.066 | 0.9646 | 0.9304 | 1.0191 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7534.066 | 0.9732 | 0.9474 | 1.0191 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7534.066 | 1.0582 | 1.1142 | 1.0191 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7534.066 | 0.9813 | 0.9633 | 1.0191 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7534.066 | 0.9547 | 0.9112 | 1.0191 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7534.066 | 0.8933 | 0.7903 | 1.0191 | |
| SUM225CWN | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7534.066 | 0.1582 | -0.6725 | 1.0191 | |
| SUM229PE | TNBC | - | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7535.066 | 0.9822 | 0.9545 | 0.7812 |