Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 5906.066 | 1.0260 | 1.0661 | 0.7892 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 5906.066 | 0.9891 | 0.9724 | 0.7892 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 5906.066 | 0.9573 | 0.8924 | 0.7892 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 5906.066 | 1.0484 | 1.1235 | 0.7892 | |
| BT-474 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 5906.066 | 0.7701 | 0.4364 | 0.7892 | |
| BT-483 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 5908.066 | 0.9444 | 0.7634 | 0.4546 | |
| BT-483 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 5908.066 | 0.9331 | 0.7175 | 0.4546 | |
| BT-483 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 5908.066 | 0.9554 | 0.8088 | 0.4546 | |
| BT-483 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 5908.066 | 0.9259 | 0.6885 | 0.4546 | |
| BT-483 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 5908.066 | 0.9355 | 0.7273 | 0.4546 | |
| BT-483 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 5908.066 | 0.9466 | 0.7726 | 0.4546 | |
| BT-483 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 5908.066 | 0.8867 | 0.5352 | 0.4546 | |
| BT-483 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 5908.066 | 0.8187 | 0.2882 | 0.4546 | |
| BT-483 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 5908.066 | 0.5453 | -0.4730 | 0.4546 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 5909.066 | 0.9974 | 0.9983 | 3.0464 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 5909.066 | 1.0399 | 1.0259 | 3.0464 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 5909.066 | 0.9470 | 0.9646 | 3.0464 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 5909.066 | 1.0364 | 1.0236 | 3.0464 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 5909.066 | 1.0607 | 1.0391 | 3.0464 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 5909.066 | 0.9754 | 0.9837 | 3.0464 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 5909.066 | 0.9973 | 0.9982 | 3.0464 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 5909.066 | 0.8940 | 0.9277 | 3.0464 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 5909.066 | 0.5234 | 0.6171 | 3.0464 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 5910.066 | 1.0528 | 1.0337 | 3.0773 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 5910.066 | 1.1053 | 1.0661 | 3.0773 |