Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7494.066 | 0.9485 | 0.8908 | 0.9416 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7494.066 | 0.9930 | 0.9852 | 0.9416 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7494.066 | 0.9622 | 0.9198 | 0.9416 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7494.066 | 0.9682 | 0.9326 | 0.9416 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 7494.066 | 0.9569 | 0.9086 | 0.9416 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 7494.066 | 0.9665 | 0.9290 | 0.9416 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7494.066 | 0.8575 | 0.6987 | 0.9416 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7494.066 | 0.5960 | 0.1544 | 0.9416 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 10419.066 | 1.0539 | 1.1565 | 0.6963 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 10419.066 | 0.9952 | 0.9863 | 0.6963 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 10419.066 | 1.0026 | 1.0075 | 0.6963 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 10419.066 | 0.9630 | 0.8945 | 0.6963 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 10419.066 | 0.9963 | 0.9894 | 0.6963 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 10419.066 | 0.9641 | 0.8977 | 0.6963 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 10419.066 | 0.9859 | 0.9597 | 0.6963 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 10419.066 | 0.8793 | 0.6626 | 0.6963 | |
| MDA-MB-134-VI | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 10419.066 | 0.8418 | 0.5617 | 0.6963 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7496.066 | 1.0287 | 1.0494 | 1.1616 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 7496.066 | 1.0241 | 1.0414 | 1.1616 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 7496.066 | 0.9986 | 0.9976 | 1.1616 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 7496.066 | 1.0303 | 1.0520 | 1.1616 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 7496.066 | 1.0352 | 1.0605 | 1.1616 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 7496.066 | 1.0045 | 1.0078 | 1.1616 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 7496.066 | 1.0339 | 1.0582 | 1.1616 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 7496.066 | 1.0232 | 1.0398 | 1.1616 |