Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7552.084 | 0.6711 | 0.4054 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7552.084 | 0.6270 | 0.3234 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7552.084 | 0.6403 | 0.3484 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7553.085 | 1.0424 | 1.0756 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7553.085 | 0.9893 | 0.9809 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7553.085 | 0.8708 | 0.7676 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7553.085 | 0.7414 | 0.5311 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7553.085 | 0.7158 | 0.4837 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7553.085 | 0.7138 | 0.4801 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7553.085 | 0.7193 | 0.4902 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7553.085 | 0.7043 | 0.4625 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7553.085 | 0.6923 | 0.4402 | 1.1198 | |
| ZR75B | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7555.084 | 0.9724 | 0.9675 | 1.7052 | |
| ZR75B | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7555.084 | 1.0305 | 1.0356 | 1.7052 | |
| ZR75B | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7555.084 | 0.7704 | 0.7163 | 1.7052 | |
| ZR75B | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7555.084 | 0.6713 | 0.5832 | 1.7052 | |
| ZR75B | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7555.084 | 0.6634 | 0.5722 | 1.7052 | |
| ZR75B | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7555.084 | 0.6825 | 0.5985 | 1.7052 | |
| ZR75B | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7555.084 | 0.6795 | 0.5945 | 1.7052 | |
| ZR75B | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7555.084 | 0.6812 | 0.5968 | 1.7052 | |
| ZR75B | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7555.084 | 0.6128 | 0.5007 | 1.7052 | |
| 21MT-1 | HER2amp | - | Methylglyoxal | 0.138 | uM | 13719.184 | 0.9695 | 0.9200 | 0.7600 | |||
| 21MT-1 | HER2amp | - | Methylglyoxal | 0.691 | uM | 13719.184 | 0.9737 | 0.9310 | 0.7600 | |||
| 21MT-1 | HER2amp | - | Methylglyoxal | 3.46 | uM | 13719.184 | 0.9936 | 0.9832 | 0.7600 | |||
| 21MT-1 | HER2amp | - | Methylglyoxal | 17.3 | uM | 13719.184 | 1.0059 | 1.0155 | 0.7600 |