Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7541.084 | 0.9533 | 0.9224 | 1.2092 | |
| T47D | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7543.084 | 1.0301 | 1.0446 | 1.3431 | |
| T47D | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7543.084 | 1.0749 | 1.1105 | 1.3431 | |
| T47D | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7543.084 | 0.9980 | 0.9970 | 1.3431 | |
| T47D | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7543.084 | 1.0519 | 1.0768 | 1.3431 | |
| T47D | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7543.084 | 1.0224 | 1.0333 | 1.3431 | |
| T47D | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7543.084 | 1.0387 | 1.0574 | 1.3431 | |
| T47D | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7543.084 | 1.1045 | 1.1536 | 1.3431 | |
| T47D | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7543.084 | 0.9960 | 0.9940 | 1.3431 | |
| T47D | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7543.084 | 0.9786 | 0.9681 | 1.3431 | |
| T47DKBLUC | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7546.084 | 0.9418 | 0.8762 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7546.084 | 0.9978 | 0.9953 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7546.084 | 0.9492 | 0.8919 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7546.084 | 0.8991 | 0.7854 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7546.084 | 0.6355 | 0.2330 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7546.084 | 0.6182 | 0.1973 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7546.084 | 0.6178 | 0.1966 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7546.084 | 0.5562 | 0.0698 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 333 | uM | 7546.084 | 0.5464 | 0.0496 | 0.9375 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7552.084 | 0.9611 | 0.9311 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7552.084 | 1.0013 | 1.0022 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7552.084 | 0.7410 | 0.5343 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7552.084 | 0.6695 | 0.4025 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7552.084 | 0.6537 | 0.3732 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7552.084 | 0.6268 | 0.3230 | 1.1307 |