Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7531.085 | 0.9309 | 0.9597 | 3.5188 | |
| SUM159PT | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7531.085 | 0.9353 | 0.9623 | 3.5188 | |
| SUM159PT | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7531.085 | 0.9645 | 0.9796 | 3.5188 | |
| SUM159PT | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7531.085 | 0.9407 | 0.9655 | 3.5188 | |
| SUM159PT | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7531.085 | 1.0061 | 1.0034 | 3.5188 | |
| SUM159PT | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7531.085 | 0.9410 | 0.9657 | 3.5188 | |
| SUM185PE | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7532.084 | 0.9967 | 0.9915 | 0.7770 | |
| SUM185PE | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7532.084 | 0.9263 | 0.8123 | 0.7770 | |
| SUM185PE | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7532.084 | 1.0104 | 1.0267 | 0.7770 | |
| SUM185PE | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7532.084 | 0.9615 | 0.9015 | 0.7770 | |
| SUM185PE | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7532.084 | 0.9457 | 0.8612 | 0.7770 | |
| SUM185PE | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7532.084 | 1.0227 | 1.0586 | 0.7770 | |
| SUM185PE | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7532.084 | 0.9763 | 0.9392 | 0.7770 | |
| SUM185PE | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7532.084 | 0.9321 | 0.8271 | 0.7770 | |
| SUM185PE | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7532.084 | 0.9233 | 0.8047 | 0.7770 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7533.084 | 1.0015 | 1.0029 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7533.084 | 1.0102 | 1.0197 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7533.084 | 1.0218 | 1.0419 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7533.084 | 1.0256 | 1.0492 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7533.084 | 1.0182 | 1.0349 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7533.084 | 1.0291 | 1.0560 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7533.084 | 1.0143 | 1.0276 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7533.084 | 0.9945 | 0.9895 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7533.084 | 0.9634 | 0.9294 | 1.0396 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7534.084 | 1.0094 | 1.0212 | 0.8905 |